Evidence map›Paper›PMID 33740387›Full record

ArticleAmerican journal of respiratory cell and molecular biology2021

Lung Epithelial Cell Transcriptional Regulation as a Factor in COVID-19-associated Coagulopathies.

Ethan S FitzGerald, Yongzhi Chen, Katherine A Fitzgerald, Amanda M Jamieson

Open access · hybridAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Tissue Factor and COVID-19 Associated Thrombosis.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Article
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  11. Understanding COVID-19-associated coagulopathy.Nature reviews. Immunology · 2022
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ethan S FitzGeraldDivision of Biology and Medicine, Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island; and.ORCID 0000-0002-0700-8561
Yongzhi ChenDivision of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester.
Katherine A FitzgeraldDivision of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester.
Amanda M JamiesonDivision of Biology and Medicine, Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island; and.ORCID 0000-0002-5781-9231
Brown University · USUniversity of Massachusetts Chan Medical School · US

Funding

The role of Sirtuins in neurodegenerative diseaseP20GM109035 · NIGMS · BROWN UNIVERSITY · PI WONG, IAN Y · 2016 to 2025
$22.6M
TRAINING IN MOLECULAR &CELL BIOLOGY &BIOCHEMISTRYT32GM007601 · NIGMS · BROWN UNIVERSITY · PI MOWRY, KIMBERLY L. · 1985 to 2019
$6.4M
Gene Regulation in Innate ImmunityR37AI067497 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, KATHERINE A. · 2015 to 2024
$4.6M
Influence of the lung microbiome on macrophage responses to lung damageR01HL126887 · NHLBI · BROWN UNIVERSITY · PI JAMIESON, AMANDA M · 2018 to 2022
$2.4M
NHLBI NIH HHS R01 HL126887NIAID NIH HHS R37 AI067497NIGMS NIH HHS P20 GM109035NIGMS NIH HHS T32 GM007601
6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become a global pandemic. In addition to the acute pulmonary symptoms of coronavirus disease (COVID-19) (the disease associated with SARS-CoV-2 infection), pulmonary and distal coagulopathies have caused morbidity and mortality in many patients. Currently, the molecular pathogenesis underlying COVID-19-associated coagulopathies are unknown. Identifying the molecular basis of how SARS-CoV-2 drives coagulation is essential to mitigating short- and long-term thrombotic risks of sick and recovered patients with COVID-19. We aimed to perform coagulation-focused transcriptome analysis of

Indexed as

Gene Expression RegulationSignal TransductionTranscription, GeneticAlveolar Epithelial CellsBlood Coagulation DisordersCell LineCOVID-19FemaleHumansInfluenza A virusInfluenza, HumanMaleSARS-CoV-2coagulation cascadecoagulopathyCOVID-19SARS-CoV-2tissue factor

Identifiers

PMID33740387
PMCPMC8456886
OpenAlexW3139259783

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.