ArticleBMC cardiovascular disorders2021
The association between serum alanine aminotransferase and hypertension: A national based cross-sectional analysis among over 21 million Chinese adults.
Article in BMC cardiovascular disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 23 citations in OpenAlex.
- Revisiting hypertension prevalence and risk factors: prevalence of hypertension and risk of diabetes in China.BMC cardiovascular disorders · 2025Article
- Association of biochemical indicators with multimorbidity in 19,624 older adult individuals with chronic diseases: a study from Jindong District, Jinhua City, China.Frontiers in public health · 2025Article
- Dietary sanguinarine supplementation improves the growth performance and intestinal immunity of broilers.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
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- The relationship between liver enzymes, prehypertension and hypertension in the Azar cohort population.BMC cardiovascular disorders · 2024Article
- Associations of ALT/AST, a marker of hepatosteatosis, with pulse rate in young women and with blood pressure in middle-aged women independently of abdominal fat accumulation and insulin resistance.Diabetology international · 2024Article
- Higher serum alanine aminotransferase levels and the incidence of hypertension: The Kailuan cohort study.American journal of preventive cardiology · 2024Article
- Effects of Hydroxytyrosol Supplementation on Performance, Fat and Blood Parameters of Broiler Chickens.Animals : an open access journal from MDPI · 2023Article
- Investigating the relationship between liver enzymes and incidence of hypertension: A population-based cohort study in Kharameh, a city in the South of Iran.Health science reports · 2023Article
- Liver-function parameters are associated with incident hypertension in a large Taiwanese population follow-up study.Journal of human hypertension · 2023Article
- Establishment and evaluation of a risk-prediction model for hypertension in elderly patients with NAFLD from a health management perspective.Scientific reports · 2022Article
- Evaluation of Relationship between Serum Liver Enzymes and Hypertension: A Cross-Sectional Study Based on Data from Rafsanjan Cohort Study.International journal of hypertension · 2022Article
- Association between serum alanine and aspartate aminotransferase and blood pressure: a cross-sectional study of Chinese freshmen.BMC cardiovascular disorders · 2021Article
- Article
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Authors and funding
17 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundInconsistent results were found in the association between serum alanine aminotransferase (ALT) and hypertension among population-based studies. This study evaluated the association between ALT and hypertension among Chinese reproductive-age population by utilizing registration data from National Free Pre-pregnancy Checkups Project in 2016-2017.
methodsThe 21,103,790 registered participants were eligible for analysis, including women who were 20-49 years old and men who were 20-59 years old with available data for ALT and blood pressure (BP). Logistic regression was conducted to estimate odds ratio (OR) for the association between ALT and hypertension as a binary outcome. Linear regression was used to examine the association between ALT and BP as a continuous outcome.
resultsIn total, 4.21% of the participants were hypertensive, and 11.67% had elevated ALT (> 40 U/L). Hypertension prevalence was 3.63% and 8.56% among participants with normal and elevated ALT levels. A strong linear relationship was found between serum ALT levels and the odds of hypertension after adjustment for potential confounders. The multivariable-adjusted ORs for hypertension were 1, 1.22 (1.21, 1.22), 1.67 (1.65 1.68), 1.78 (1.76, 1.80), and 1.92 (1.90, 1.94) in participants with ALT levels of ≤ 20, 20.01-40, 40.01-60, 60.01-80, and > 80 U/L, respectively. Systolic and diastolic BPs rose by 1.83 and 1.20 mmHg on average, for each 20 U/L increase in ALT (P
conclusionsOur cross-sectional analysis suggested a linear association between serum ALT and hypertension or BP, which indicated that abnormal liver metabolism marked by elevated serum ALT could play a role in hypertension or elevated BP condition.
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