ArticleCommunications biology2021
A combinatorial action of GmMYB176 and GmbZIP5 controls isoflavonoid biosynthesis in soybean (Glycine max).
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 61 citations in OpenAlex.
- GmMYB4 Positively Regulates Isoflavone Biosynthesis via the GmMAPK6-GmMYB4-MBW Module in Soybean.Plant biotechnology journal · 2026Article
- Small auxin-up RNA promotesFrontiers in plant science · 2026Article
- Identification of theFrontiers in plant science · 2026Article
- Aquilaria sinensis MYB-Like Transcription Factor AsMYB1 Promotes 2-(2-Phenylethyl)Chromone Biosynthesis Through Interacting With 14-3-3 Family Protein AsGRF1.Plant biotechnology journal · 2025Article
- Phloem-specific translational regulation of soybean nodulation: Insights from a phloem-targeted TRAP-seq approach.Plant physiology · 2025Article
- Overexpression ofPlants (Basel, Switzerland) · 2025Article
- An R2R3-type MYB transcription factor, GmMYB77, negatively regulates isoflavone accumulation in soybean [Glycine max (L.) Merr.].Plant biotechnology journal · 2025Article
- Molecular insights into postharvest seed coat darkening in common beans: a look beyond theFrontiers in plant science · 2025Article
- Integrative Analyses of Metabolome and Transcriptome Reveal Regulatory Network of Puerarin Biosynthesis inMolecules (Basel, Switzerland) · 2024Article
- Bioinformatics Identification and Expression Analysis of Acetyl-CoA Carboxylase Reveal Its Role in Isoflavone Accumulation during Soybean Seed Development.International journal of molecular sciences · 2024Article
- Fine-tuning plant valuable secondary metabolite biosynthesis via small RNA manipulation: strategies and potential.Planta · 2024Review
- Differentially Expressed Genes Related to Isoflavone Biosynthesis in a Soybean Mutant Revealed by a Comparative Transcriptomic Analysis.Plants (Basel, Switzerland) · 2024Article
- The GmSTF1/2-GmBBX4 negative feedback loop acts downstream of blue-light photoreceptors to regulate isoflavonoid biosynthesis in soybean.Plant communications · 2024Article
- Isoflavonoid metabolism in leguminous plants: an update and perspectives.Frontiers in plant science · 2024Review
- Biosynthesis and metabolic engineering of isoflavonoids in model plants and crops: a review.Frontiers in plant science · 2024Review
- Investigation ofACS omega · 2023Article
- RNA-Seq Dissects Incomplete Activation of Phytoalexin Biosynthesis by the Soybean Transcription Factors GmMYB29A2 and GmNAC42-1.Plants (Basel, Switzerland) · 2023Article
- Comparative Transcriptome Analysis ofBiomolecules · 2023Article
- The B-box transcription factor IbBBX29 regulates leaf development and flavonoid biosynthesis in sweet potato.Plant physiology · 2023Article
- Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GmMYB176 is an R1 MYB transcription factor that regulates multiple genes in the isoflavonoid biosynthetic pathway, thereby affecting their levels in soybean roots. While GmMYB176 is important for isoflavonoid synthesis, it is not sufficient for the function and requires additional cofactor(s). The aim of this study was to identify the GmMYB176 interactome for the regulation of isoflavonoid biosynthesis in soybean. Here, we demonstrate that a bZIP transcription factor GmbZIP5 co-immunoprecipitates with GmMYB176 and shows protein-protein interaction in planta. RNAi silencing of GmbZIP5 reduced the isoflavonoid level in soybean hairy roots. Furthermore, co-overexpression of GmMYB176 and GmbZIP5 enhanced the level of multiple isoflavonoid phytoallexins including glyceollin, isowighteone and a unique O-methylhydroxy isoflavone in soybean hairy roots. These findings could be utilized to develop biotechnological strategies to manipulate the metabolite levels either to enhance plant defense mechanisms or for human health benefits in soybean or other economically important crops.
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