ArticleJournal of gastrointestinal cancer2022
Nano-peroxidase a Promising Anti-inflammatory and Antibacterial Agent Against Bacteria and Inflammation Related to Colorectal Cancer.
Article in Journal of gastrointestinal cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 9 citations in OpenAlex.
- Bacteria-tumor symbiosis destructible novel nanocatalysis drug delivery systems for effective tumor therapy.Nanomedicine (London, England) · 2025Review
- Nano Parthenolide Improves Intestinal Barrier Function of Sepsis by Inhibiting Apoptosis and ROS via 5-HTR2A.International journal of nanomedicine · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColorectal cancer (CRC) is one of the most common causes of cancer death in the world. Although genes are considered the most importantcauses that contribute to CRC, the intestinal microorganisms are an important player. Recently, various studies ensured the role of microbial infection and the ensuing inflammation in colon cancer initiation and progression. This present study tries to introduce a cheap nano-peroxidase (an antioxidant enzyme) produced from natural sources as efficient and safe antibacterial and anti-inflammatory agent against bacteria and inflammation related to colorectal cancer.
methodsSilica nanoparticles were prepared from rice straw. Peroxidase extracted from the dry onion scales was then immobilized on the prepared nanosilica (nano-peroxidase). The antibacterial activity of the prepared nano-peroxidase was tested against the four horsemen bacteria in CRC, Fusobacterium nucleatum, Escherichia coli, Bacteroides fragilis, and Salmonella enterica. The in vitro anti-inflammatory activity of the prepared nano-peroxidase also tests through performing inhibition of albumin denaturation test.
resultsThe prepared nano-peroxidase showed high antibacterial activity against the tested bacteria in presence of very low concentration of H2O2. Immobilization increased the peroxidase stability and protected it from hydrolysis enzymes produced by the bacteria. The prepared nano-peroxidase interestingly showed significant higher anti-inflammatory activity than that of the standard (Aspirin).
conclusionNano-peroxidase can be considered a promising safe anti-inflammatory and antibacterial agent against bacteria and inflammation related to colorectal cancer.
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Registered trials
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