Evidence map›Paper›PMID 33745084›Full record

ArticleClinical rheumatology2021

Glutathione S-transferase, catalase, and mitochondrial superoxide dismutase gene polymorphisms modulate redox potential in systemic lupus erythematosus patients from Manaus, Amazonas, Brazil.

Marco Aurélio Almeida de Oliveira, Neila Hiraishi Mallmann, Giselle Katiane Bonfim Bacellar de Souza, Thiago de Jesus Bacha, Emerson Silva Lima, Domingos Sávio Nunes de Lima, Luiz Fernando de Souza Passos, Marilda de Souza Gonçalves, José Pereira de Moura Neto

Abstract read
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In one paragraph

Article in Clinical rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Marco Aurélio Almeida de OliveiraFaculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas, Avenida General Rodrigo Otávio Jordão Ramos 6200 - Coroado, Manaus - AM, CEP: 69067-005, Brazil.
Neila Hiraishi MallmannFaculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas, Avenida General Rodrigo Otávio Jordão Ramos 6200 - Coroado, Manaus - AM, CEP: 69067-005, Brazil.
Giselle Katiane Bonfim Bacellar de SouzaFaculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas, Avenida General Rodrigo Otávio Jordão Ramos 6200 - Coroado, Manaus - AM, CEP: 69067-005, Brazil.
Thiago de Jesus BachaFaculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas, Avenida General Rodrigo Otávio Jordão Ramos 6200 - Coroado, Manaus - AM, CEP: 69067-005, Brazil.
Emerson Silva LimaFaculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas, Avenida General Rodrigo Otávio Jordão Ramos 6200 - Coroado, Manaus - AM, CEP: 69067-005, Brazil.
Domingos Sávio Nunes de LimaFaculdade de Medicina, Universidade Federal do Amazonas, Manaus, Amazonas, Brazil.
Luiz Fernando de Souza PassosFaculdade de Medicina, Universidade Federal do Amazonas, Manaus, Amazonas, Brazil.
Marilda de Souza GonçalvesCentro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil.
José Pereira de Moura NetoFaculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas, Manaus, Amazonas, Brazil. jp-mn@ufam.edu.br.ORCID http://orcid.org/0000-0003-2177-7292
Universidade Federal do Amazonas · BRFundação Oswaldo Cruz · BR

Funding

Fundação de Amparo à Pesquisa do Estado do Amazonas (BR) 1094/2013
6 · The paper itself

Abstract

objectiveTo investigate the frequency of glutathione S-transferase (GST), catalase, and SOD2 genetic polymorphisms and their correlation with SLE.

methodsA total of 290 females (patients = 151; controls= 139) were recruited. Multiplex PCR was performed for genotyping GSTM1 and GSTT1 genes, whereas real-time qPCR was used for determination of SNPs: CAT C262T, SOD2 C47T, GSTP1 A313G and GSTP1 IVS6 -C16T.

resultsThiol levels are decreased in SLE patients (p<0.001), while MDA levels were significantly higher (p<0.001) and those carrying the polymorphisms had higher rates of oxidative stress. Patients with double null deletion GSTT1

conclusionsThe deletion GSTT1

Indexed as

Hydrogen PeroxideLupus Erythematosus, SystemicBrazilCase-Control StudiesCatalaseFemaleGenetic Predisposition to DiseaseGenotypeGlutathione S-Transferase piGlutathione TransferaseHumansOxidation-ReductionPolymorphism, Single NucleotideSuperoxide DismutaseCatalaseGlutathione S-Transferase piGlutathione TransferaseHydrogen PeroxideSuperoxide DismutaseAutoimmune diseasesGene polymorphismSystemic lupus erythematosus

Identifiers

PMID33745084
OpenAlexW3137796836

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.