Designed whole-cell-catalysis-assisted synthesis of 9,11-secosterols.

Marek Kõllo, Marje Kasari, Villu Kasari, Tõnis Pehk, Ivar Järving, Margus Lopp, Arvi Jõers, Tõnis Kanger

Abstract read

In one paragraph

Article in Beilstein journal of organic chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

New Steroid and Isocoumarin from the Mangrove Endophytic FungusMolecules (Basel, Switzerland) · 2022
Article

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Marek KõlloDepartment of Chemistry and Biotechnology, School of Science, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia.

Marje KasariInstitute of Technology, University of Tartu, Nooruse 1, 50104 Tartu, Estonia.ORCID https://orcid.org/0000-0002-2177-3753

Villu KasariInstitute of Technology, University of Tartu, Nooruse 1, 50104 Tartu, Estonia.ORCID https://orcid.org/0000-0002-2970-2001

Tõnis PehkNational Institute of Chemical Physics and Biophysics, Akadeemia tee 23, 12618 Tallinn, Estonia.

Ivar JärvingDepartment of Chemistry and Biotechnology, School of Science, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia.ORCID https://orcid.org/0000-0001-6047-4759

Margus LoppDepartment of Chemistry and Biotechnology, School of Science, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia.

Arvi JõersInstitute of Technology, University of Tartu, Nooruse 1, 50104 Tartu, Estonia.ORCID https://orcid.org/0000-0003-2083-3977

Tõnis KangerDepartment of Chemistry and Biotechnology, School of Science, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia.ORCID https://orcid.org/0000-0001-5339-9682

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A method for the synthesis of 9,11-secosteroids starting from the natural corticosteroid cortisol is described. There are two key steps in this approach, combining chemistry and synthetic biology. Stereo- and regioselective hydroxylation at C9 (steroid numbering) is carried out using whole-cell biocatalysis, followed by the chemical cleavage of the C-C bond of the vicinal diol. The two-step method features mild reaction conditions and completely excludes the use of toxic oxidants.

Indexed as

chemoenzymatic synthesiscortisolhydroxylationsecosterolwhole-cell catalysis

Identifiers

PMID33747232

DOI10.3762/bjoc.17.52

PMCPMC7940815

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