Evidence map›Paper›PMID 33747979›Full record

ArticleFrontiers in cellular and infection microbiology2021

Combination With Tomatidine Improves the Potency of Posaconazole Against

Marianne Rocha-Hasler, Gabriel Melo de Oliveira, Aline Nefertiti da Gama, Ludmila Ferreira de Almeida Fiuza, Anna Frieda Fesser, Monica Cal, Romina Rocchetti, Raiza Brandão Peres, Xue Li Guan, Marcel Kaiser and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. NParasitology · 2024
    Article
  4. Review
  5. Review
  6. Review
  7. Overexpression ofInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Marianne Rocha-HaslerLaboratório de Biologia Celular, Instituto Oswaldo Cruz (IOC/Fiocruz), Pavilhão Cardoso Fontes, Rio de Janeiro, Brazil.
Gabriel Melo de OliveiraLaboratório de Biologia Celular, Instituto Oswaldo Cruz (IOC/Fiocruz), Pavilhão Cardoso Fontes, Rio de Janeiro, Brazil.
Aline Nefertiti da GamaLaboratório de Biologia Celular, Instituto Oswaldo Cruz (IOC/Fiocruz), Pavilhão Cardoso Fontes, Rio de Janeiro, Brazil.
Ludmila Ferreira de Almeida FiuzaLaboratório de Biologia Celular, Instituto Oswaldo Cruz (IOC/Fiocruz), Pavilhão Cardoso Fontes, Rio de Janeiro, Brazil.
Anna Frieda FesserParasite Chemotherapy Unit, Swiss Tropical and Public Health Institute, Medical Parasitology and Infection Biology, Basel, Switzerland.
Monica CalParasite Chemotherapy Unit, Swiss Tropical and Public Health Institute, Medical Parasitology and Infection Biology, Basel, Switzerland.
Romina RocchettiParasite Chemotherapy Unit, Swiss Tropical and Public Health Institute, Medical Parasitology and Infection Biology, Basel, Switzerland.
Raiza Brandão PeresLaboratório de Biologia Celular, Instituto Oswaldo Cruz (IOC/Fiocruz), Pavilhão Cardoso Fontes, Rio de Janeiro, Brazil.
Xue Li GuanSystems Biology of Lipid Metabolism in Human Health and Diseases Laboratory, Lee Kong Chian School of Medicine, Singapore, Singapore.
Marcel KaiserParasite Chemotherapy Unit, Swiss Tropical and Public Health Institute, Medical Parasitology and Infection Biology, Basel, Switzerland.
Maria de Nazaré Correia SoeiroLaboratório de Biologia Celular, Instituto Oswaldo Cruz (IOC/Fiocruz), Pavilhão Cardoso Fontes, Rio de Janeiro, Brazil.
Pascal MäserParasite Chemotherapy Unit, Swiss Tropical and Public Health Institute, Medical Parasitology and Infection Biology, Basel, Switzerland.
Fundação Oswaldo Cruz · BRUniversity of Basel · CHSwiss Tropical and Public Health Institute · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Azoles such as posaconazole (Posa) are highly potent against

Indexed as

Chagas DiseaseTrypanosoma cruziAnimalsHumansMiceTomatineTriazolesposaconazoletomatidineTomatineTriazolesChagas diseasedrug combinationlipid biosynthesis inhibitorT. cruzitomatidine hydrochloride

Identifiers

PMID33747979
PMCPMC7970121
OpenAlexW3135253415

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.