Evidence map›Paper›PMID 33748495›Full record

ArticleHeliyon2021

Association between carriers of the G allele of the + 45T> G variant of the ADIPOQ gene (

Jamila Benvegnú Bruno, Emanuelle Schneider Dal Ponte, Vanessa Retamoso, Patrícia Maurer, Lyana Feijoó Berro, Vanusa Manfredini, Jacqueline da Costa Escobar Piccoli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jamila Benvegnú BrunoPostgraduate Program in Biochemistry, Federal University of Pampa, BR 472, Km 592, P.O. BOX 118, Zip Code 97508-000, Uruguaiana, Rio Grande do Sul, Brazil.
Emanuelle Schneider Dal PontePostgraduate Program in Biochemistry, Federal University of Pampa, BR 472, Km 592, P.O. BOX 118, Zip Code 97508-000, Uruguaiana, Rio Grande do Sul, Brazil.
Vanessa RetamosoPostgraduate Program in Biochemistry, Federal University of Pampa, BR 472, Km 592, P.O. BOX 118, Zip Code 97508-000, Uruguaiana, Rio Grande do Sul, Brazil.
Patrícia MaurerPostgraduate Program in Biochemistry, Federal University of Pampa, BR 472, Km 592, P.O. BOX 118, Zip Code 97508-000, Uruguaiana, Rio Grande do Sul, Brazil.
Lyana Feijoó BerroPostgraduate Program in Biochemistry, Federal University of Pampa, BR 472, Km 592, P.O. BOX 118, Zip Code 97508-000, Uruguaiana, Rio Grande do Sul, Brazil.
Vanusa ManfrediniPostgraduate Program in Biochemistry, Federal University of Pampa, BR 472, Km 592, P.O. BOX 118, Zip Code 97508-000, Uruguaiana, Rio Grande do Sul, Brazil.
Jacqueline da Costa Escobar PiccoliPostgraduate Program in Biochemistry, Federal University of Pampa, BR 472, Km 592, P.O. BOX 118, Zip Code 97508-000, Uruguaiana, Rio Grande do Sul, Brazil.
Universidade Federal do Pampa · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsinvestigate the association between the +45T > G variant of the ADIPOQ gene and the metabolic syndrome (MS) in patients with sickle cell trait (SCT). 33 patients with SCT and 35 control group participated in the study. Lower levels of HDL and adiponectin were observed in patients with G allele and sickle cell trait. There were no differences between the prevalence of MS between the groups and there was no association between the +45T > G variant of the ADIPOQ gene and MS risk allele. MATERIALS AND

methodsParticipants with and without sickle cell anemia answered a questionnaire, performed anthropometric and laboratory analyzes. They were genotyped for the +45T > G variant of the ADIPOQ gene and evaluated for the presence or absence of metabolic syndrome. The study was approved by the Research Ethics Committee of UNIPAMPA (RS/Brazil). KEY

findingsThe GG + TG genetic model, it was associated with lower levels of adiponectin and HDL cholesterol in the SCT group. There was no association between the other studied markers and MS. SIGNIFICANCE: For the first time, an association was demonstrated between the G allele of the +45T > G variant of the ADIPOQ gene and a worse cardiometabolic profile (lower serum concentrations of adiponectin and HDL cholesterol) in patients with sickle cell trait.

Indexed as

+45T>G variant in ADIPOQ geneAdiponectinMetabolic syndromers 2241766Sickle cell trait

Identifiers

PMID33748495
PMCPMC7966990
OpenAlexW3138418526

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.