Evidence map›Paper›PMID 33748879›Full record

ReviewDrug delivery and translational research2021

Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control.

Kai-Chieh Yang, Jung-Chen Lin, Hsiao-Han Tsai, Chung-Yao Hsu, Vicky Shih, Che-Ming Jack Hu

Abstract readReview
In one paragraph

Review in Drug delivery and translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. PROTAC targeted protein degraders: the past is prologue.Nature reviews. Drug discovery · 2022
    Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kai-Chieh YangTaiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, 112304, Taiwan.
Jung-Chen LinInstitute of Biomedical Sciences, Academia Sinica, Taipei, 115201, Taiwan.
Hsiao-Han TsaiTaiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, 112304, Taiwan.
Chung-Yao HsuTaiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, 112304, Taiwan.
Vicky ShihInstitute of Biomedical Sciences, Academia Sinica, Taipei, 115201, Taiwan.
Che-Ming Jack HuTaiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, 112304, Taiwan. chu@ibms.sinica.edu.tw.ORCID http://orcid.org/0000-0002-0988-7029

Funding

Academia Sinica AS-CDA-105-L06Ministry of Science and Technology, Taiwan 108-2119-M-001-016Ministry of Science and Technology, Taiwan 109-2321-B-002-033
6 · The paper itself

Abstract

The COVID-19 pandemic's high mortality rate and severe socioeconomic impact serve as a reminder of the urgent need for effective countermeasures against viral pandemic threats. In particular, effective antiviral therapeutics capable of stopping infections in its tracks is critical to reducing infection fatality rate and healthcare burden. With the field of drug delivery witnessing tremendous advancement in the last two decades owing to a panoply of nanotechnology advances, the present review summarizes and expounds on the research and development of therapeutic nanoformulations against various infectious viral pathogens, including HIV, influenza, and coronaviruses. Specifically, nanotechnology advances towards improving pathogen- and host-targeted antiviral drug delivery are reviewed, and the prospect of achieving effective viral eradication, broad-spectrum antiviral effect, and resisting viral mutations are discussed. As several COVID-19 antiviral clinical trials are met with lackluster treatment efficacy, nanocarrier strategies aimed at improving drug pharmacokinetics, biodistributions, and synergism are expected to not only contribute to the current disease treatment efforts but also expand the antiviral arsenal against other emerging viral diseases.

Indexed as

AnimalsAntiviral AgentsCOVID-19Drug Delivery SystemsHost-Pathogen InteractionsHumansNanoparticlesNanotechnologyPandemicsVirus DiseasesVirus ReplicationAntiviral AgentsAntiviralsAntiviral stateCOVID-19Drug deliveryHost-targeted antiviralNanodecoyNanoparticlesNanosponge

Identifiers

PMID33748879
PMCPMC7982277

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.