Evidence map›Paper›PMID 33749593›Full record

ArticleeLife2021

Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca

Bassam Tawfik, Joana S Martins, Sébastien Houy, Cordelia Imig, Paulo S Pinheiro, Sonja M Wojcik, Nils Brose, Benjamin H Cooper, Jakob Balslev Sørensen

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
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  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Synaptotagmin 7 Sculpts Short-Term Plasticity at a High Probability Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  10. All SNAP25 molecules in the vesicle-plasma membrane contact zone change conformation during vesicle priming.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
  12. Article
  13. Forty years of the adrenal chromaffin cell through ISCCB meetings around the world.Pflugers Archiv : European journal of physiology · 2023
    Review
  14. Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Bassam TawfikDepartment of Neuroscience, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-1193-8494
Joana S Martins *Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark.
Sébastien Houy *Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-3639-1931
Cordelia Imig *Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.ORCID 0000-0001-7351-8706
Paulo S PinheiroDepartment of Neuroscience, University of Copenhagen, Copenhagen, Denmark.
Sonja M WojcikDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Nils BroseDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Benjamin H CooperDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Jakob Balslev SørensenDepartment of Neuroscience, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-5465-3769
University of Copenhagen · DKMax Planck Institute of Experimental Medicine · DE

Funding

Independent Research Fund Denmark 0134-00141ALundbeckfonden R221-2016-1202Lundbeckfonden R34-A3740Novo Nordisk Foundation NNF19OC0058298University of Copenhagen 2016 excellence program KU2016
6 · The paper itself

Abstract

Synaptotagmins confer calcium-dependence to the exocytosis of secretory vesicles, but how coexpressed synaptotagmins interact remains unclear. We find that synaptotagmin-1 and synaptotagmin-7 when present alone act as standalone fast and slow Ca

Indexed as

AnimalsCalciumCell MembraneChromaffin CellsElectron Microscope TomographyExocytosisIntracellular Signaling Peptides and ProteinsMembrane FusionMiceMice, Inbred C57BLNerve Tissue ProteinsSecretory VesiclesSynaptotagminsCalciumIntracellular Signaling Peptides and ProteinsNerve Tissue ProteinsSynaptotagminsUnc13b protein, mousecapacitance measurementschromaffin cellmouseneuroscienceneurotransmitter releaseSNARE-proteinssynaptotagmin-7vesicle priming

Identifiers

PMID33749593
PMCPMC8012061
OpenAlexW3139527893

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.