Evidence map›Paper›PMID 33755012›Full record

ArticleeLife2021

A spontaneous genetically induced epiallele at a retrotransposon shapes host genome function.

Tessa M Bertozzi, Nozomi Takahashi, Geula Hanin, Anastasiya Kazachenka, Anne C Ferguson-Smith

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Germline variants inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tessa M BertozziDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0003-2900-6740
Nozomi TakahashiDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
Geula HaninDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
Anastasiya KazachenkaDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
Anne C Ferguson-SmithDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-7608-5894
University of Cambridge · GB

Funding

Biotechnology and Biological Sciences Research Council BB/G020930/1Biotechnology and Biological Sciences Research Council BB/R009996/1Medical Research Council MR/R009791/1Medical Research Council MR/W003783/1Wellcome Trust 210757/Z/18/Z
6 · The paper itself

Abstract

Intracisternal A-particles (IAPs) are endogenous retroviruses (ERVs) responsible for most insertional mutations in the mouse. Full-length IAPs harbour genes flanked by long terminal repeats (LTRs). Here, we identify a solo LTR IAP variant (

Indexed as

AnimalsDNA MethylationEndogenous RetrovirusesEpigenesis, GeneticFemaleGene ExpressionMaleMiceMice, Inbred C57BLRetroelementsTerminal Repeat SequencesZinc FingersRetroelementschromosomesDNA methylationendogenous retrovirusepiallelegene expressiongeneticsgenomicsIAPmousetransposable element

Identifiers

PMID33755012
PMCPMC8084528
OpenAlexW3136791201

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.