ArticleProceedings of the National Academy of Sciences of the United States of America2021
Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 168 papers.
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168citing papers in PubMed
18.7field-weighted citation impact, top 1% of its field
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Who cites it
168 citing papers in PubMed, 231 citations in OpenAlex.
- The mechano-immune-vesicle regulatory circuit: a systems framework for bone homeostasis and regeneration.Bioactive materials · 2026Review
- A nucleic acid regulation strategy under mechanical stress for intervertebral disc degeneration treatment.Bioactive materials · 2026Article
- Roles of Piezo channels in dentofacial deformity: Onset, orthodontic treatment, and associated diseases.Genes & diseases · 2026Review
- Mechanical stress-mediated ferritinophagy aggravates cartilage endplate degeneration via a PIEZO1-NCOA4-ZBP1 axis.Autophagy · 2026Article
- Obesity-Associated Osteoarthritis: Mechanical-Metabolic Pathogenesis, Obesity Memory and Dual-Target Therapy.Current obesity reports · 2026Review
- Piezo1 in Peripheral and Central Sensitisation: Implications for Chronic Pain.Bioengineering (Basel, Switzerland) · 2026Review
- Submolecular modulation of PIEZO1 mechanotransduction with wireless tailor-made nanoswitches.Bioactive materials · 2026Article
- Review
- Piezo ion channels in the digestive system: Mechanotransduction pathways and therapeutic targeting strategies.Genes & diseases · 2026Review
- Piezo1 accelerates osteoarthritis progression via promotion of HBB-dependent oxidative phosphorylation.The Journal of biological chemistry · 2026Article
- Review
- From Joint Loading to Osteoarthritis: A Multiscale Review of Knee Mechanobiology and Digital Modelling.International journal of molecular sciences · 2026Review
- Piezo1 Mechanotransduction in Skeletal Muscle: Convergence with Noncoding RNA Regulation in Myogenesis, Regeneration, and Sarcopenia.International journal of molecular sciences · 2026Review
- LPA/LPAR signaling drives temporomandibular disorders-like pain through regulating the expression and sensitization of PIEZO2.Science advances · 2026Article
- Anti-Complement, Anti-Oxidative, and Anti-Inflammatory Activities of the Ethanol Extract ofPlants (Basel, Switzerland) · 2026Article
- [Research progress on clinical transformation of Piezo1 in osteoarthritis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- A multiscale modeling approach to study the role of mechanics and inflammation in the pathophysiology of articular cartilage.Computers in biology and medicine · 2026Article
- Role of collagen VI and IX in mechanotransduction in the cartilage microenvironments: A multiscale in silico examination.Journal of orthopaedic translation · 2026Article
- Mechanistic Links Underlying the Comorbidity of Osteoporosis and Osteoarthritis: Cell Fate Plasticity Driven by the Subchondral Bone Microenvironment.International journal of molecular sciences · 2026Review
- NF-κB-Dependent Transcriptional Regulation of Piezo1 Mediates Bacterial Clearance on Infected Lung Stiffness.American journal of respiratory cell and molecular biology · 2026Article
108 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 2 institutions in 1 country.
Whasil LeeDepartment of Neurology, Duke University, Durham, NC 27710; whasil_lee@urmc.rochester.edu wolfgang@neuro.duke.edu.
Robert J NimsDepartment of Orthopaedic Surgery, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110.
Alireza SavadipourDepartment of Orthopaedic Surgery, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110.ORCID 0000-0002-6395-6558
Qiaojuan ZhangDepartment of Neurology, Duke University, Durham, NC 27710.ORCID 0000-0003-4260-8754
Holly A LeddyDepartment of Orthopedics, Duke University, Durham, NC 27710.ORCID 0000-0002-1604-2876
Fang LiuDepartment of Neurobiology, Duke University, Durham, NC 27710.
Amy L McNultyDepartment of Orthopedics, Duke University, Durham, NC 27710.ORCID 0000-0003-0556-0106
Yong ChenDepartment of Neurology, Duke University, Durham, NC 27710.ORCID 0000-0001-8824-7187
Farshid GuilakDepartment of Orthopaedic Surgery, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110.ORCID 0000-0001-7380-0330
Wolfgang B LiedtkeDepartment of Neurology, Duke University, Durham, NC 27710; whasil_lee@urmc.rochester.edu wolfgang@neuro.duke.edu.
Duke University · USWashington University in St. Louis · US
Funding
Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)P30AR069655 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2016 to 2026
$7.8MVISCOELASTIC PROPERTIES OF NORMAL AND OA CHONDRONSR01AG015768 · NIA · WASHINGTON UNIVERSITY · PI GUILAK, FARSHID · 1998 to 2022
$7.7MWashington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Christine T. Pham · 2018 to 2026
$7.6MResource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8MOBESITY, BIOMECHANICS, AND INFLAMMATION IN OSTEOARTHRITISR01AG046927 · NIA · WASHINGTON UNIVERSITY · PI GUILAK, FARSHID · 2013 to 2023
$3.2MDeconstructing Cartilage Mechanotransduction by Piezo ChannelsR01AR072999 · NIAMS · WASHINGTON UNIVERSITY · PI GUILAK, FARSHID · 2020 to 2024
$2.9MSexual dimorphism of neuroimmune interactions in temporomandibular joint disorders pain: contribution of a newly identified female-specific pain signaling axis IL23/IL17A/TRPV1R01DE027454 · NIDCR · DUKE UNIVERSITY · PI CHEN, YONG · 2018 to 2022
$2.7MMechanotransduction in Meniscus Health and RepairR01AR073221 · NIAMS · DUKE UNIVERSITY · PI MCNULTY, AMY L · 2019 to 2023
$2.1MEngineering cartilage mechanotransduction for treatment of chondrocyte injuryR21AR065653 · NIAMS · DUKE UNIVERSITY · PI LIEDTKE, WOLFGANG B. · 2014 to 2015
$382kPiezo channel activation and mechanotransduction in chondrocytes during traumatic injuryF32AR074240 · NIAMS · WASHINGTON UNIVERSITY · PI NIMS, ROBERT JOHN · 2018 to 2020
$196kNIAMS NIH HHS F32 AR074240NIAMS NIH HHS P30 AR069655NIAMS NIH HHS P30 AR073752NIAMS NIH HHS P30 AR074992NIAMS NIH HHS R01 AR072999NIAMS NIH HHS R01 AR073221NIAMS NIH HHS R21 AR065653NIA NIH HHS R01 AG015768NIA NIH HHS R01 AG046927NIDCR NIH HHS R01 DE027454
Abstract
Osteoarthritis (OA) is a painful and debilitating condition of synovial joints without any disease-modifying therapies [A. M. Valdes, T. D. Spector,
Indexed as
Activating Transcription Factor 2AnimalsCalciumCartilage, ArticularCells, CulturedChondrocytesFemaleGene Knockdown TechniquesHumansInterleukin-1alphaIon ChannelsMechanotransduction, CellularOsteoarthritisPrimary Cell CulturePromoter Regions, GeneticSus scrofaActivating Transcription Factor 2CalciumInterleukin-1alphaIon Channelsinterleukin-1osteoarthritisPIEZO1Piezo1 gene regulation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.