Evidence map›Paper›PMID 33758644›Full record

ReviewWorld journal of diabetes2021

Bidirectional link between diabetes mellitus and coronavirus disease 2019 leading to cardiovascular disease: A narrative review.

Vijay Viswanathan, Anudeep Puvvula, Ankush D Jamthikar, Luca Saba, Amer M Johri, Vasilios Kotsis, Narendra N Khanna, Surinder K Dhanjil, Misha Majhail, Durga Prasanna Misra and 6 more

Open access · diamondAbstract readReview
In one paragraph

Review in World journal of diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  5. Stroke, infections, and New Mechanisms: a Narrative Review.Current neurology and neuroscience reports · 2025
    Review
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  12. Diabetes mellitus and the risk of post-acute COVID-19 hospitalizations-a nationwide cohort study.Diabetic medicine : a journal of the British Diabetic Association · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Vijay ViswanathanM Viswanathan Hospital for Diabetes, M Viswanathan Diabetes Research Centre, Chennai 600013, India.
Anudeep PuvvulaAnnu's Hospitals for Skin and Diabetes, Nellore 524101, Andhra Pradesh, India.
Ankush D JamthikarDepartment of Electronics and Communications, Visvesvaraya National Institute of Technology, Nagpur 440010, Maharashtra, India.
Luca SabaDepartment of Radiology, University of Cagliari, Monserrato 09045, Cagliari, Italy.
Amer M JohriDepartment of Medicine, Division of Cardiology, Queen's University, Kingston, ON K7L 3N6, Canada.
Vasilios Kotsis3rd Department of Internal Medicine, Hypertension Center, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki 541-24, Greece.
Narendra N KhannaDepartment of Cardiology, Indraprastha APOLLO Hospitals, New Delhi 110020, India.
Surinder K DhanjilStroke Diagnosis and Monitoring Division, AtheroPoint™ LLC, CA 95661, United States.
Misha MajhailStroke Diagnosis and Monitoring Division, AtheroPoint™, Roseville, CA 95661, United States.
Durga Prasanna MisraDepartment of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India.
Vikas AgarwalDepartments of Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India.
George D KitasAcademic Affairs, Dudley Group NHS Foundation Trust, Dudley DY1 2HQ, United Kingdom.
Aditya M SharmaDivision of Cardiovascular Medicine, University of Virginia, Charlottesville, VA 22908, United States.
Raghu KolluriOhioHealth Heart and Vascular, Ohio, OH 43082, United States.
Subbaram NaiduElectrical Engineering Department, University of Minnesota, Duluth, MN 55812, United States.
Jasjit S SuriStroke Diagnosis and Monitoring Division, AtheroPoint™, Roseville, CA 95661, United States. jasjit.suri@atheropoint.com.
Queen's University · CASanjay Gandhi Post Graduate Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) is a global pandemic where several comorbidities have been shown to have a significant effect on mortality. Patients with diabetes mellitus (DM) have a higher mortality rate than non-DM patients if they get COVID-19. Recent studies have indicated that patients with a history of diabetes can increase the risk of severe acute respiratory syndrome coronavirus 2 infection. Additionally, patients without any history of diabetes can acquire new-onset DM when infected with COVID-19. Thus, there is a need to explore the bidirectional link between these two conditions, confirming the vicious loop between "DM/COVID-19". This narrative review presents (1) the bidirectional association between the DM and COVID-19, (2) the manifestations of the DM/COVID-19 loop leading to cardiovascular disease, (3) an understanding of primary and secondary factors that influence mortality due to the DM/COVID-19 loop, (4) the role of vitamin-D in DM patients during COVID-19, and finally, (5) the monitoring tools for tracking atherosclerosis burden in DM patients during COVID-19 and "COVID-triggered DM" patients. We conclude that the bidirectional nature of DM/COVID-19 causes acceleration towards cardiovascular events. Due to this alarming condition, early monitoring of atherosclerotic burden is required in "Diabetes patients during COVID-19" or "new-onset Diabetes triggered by COVID-19 in Non-Diabetes patients".

Indexed as

Atherosclerotic burdenBidirectional associationCardiovascular diseaseCOVID-19Diabetes mellitusImaging tools

Identifiers

PMID33758644
PMCPMC7958478
OpenAlexW3134339621

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.