Evidence map›Paper›PMID 33762339›Full record

ArticleScience advances2021

Ca

Aurélia C Balestra, Konstantinos Koussis, Natacha Klages, Steven A Howell, Helen R Flynn, Marcus Bantscheff, Carla Pasquarello, Abigail J Perrin, Lorenzo Brusini, Patrizia Arboit and 9 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Phosphorylation in theJournal of proteome research · 2024
    Pooled it
  2. Review
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  4. Review
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  6. Physiology of invasiveFrontiers in cellular and infection microbiology · 2026
    Review
  7. Frontiers in parasitology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Comparative immunological roles of TEP1 inFrontiers in immunology · 2025
    Review
  18. Article
  19. Orthologs ofMicrobiology spectrum · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 4 countries.

Aurélia C BalestraDepartment of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.ORCID 0000-0001-9934-6404
Konstantinos KoussisMalaria Biochemistry Laboratory, The Francis Crick Institute, London NW1 1AT, UK. konstantinos.kousis@crick.ac.uk mike.blackman@crick.ac.uk mathieu.brochet@unige.ch.ORCID 0000-0002-6737-8724
Natacha KlagesDepartment of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.
Steven A HowellMass Spectrometry Proteomics Platform, The Francis Crick Institute, London, UK.
Helen R FlynnMass Spectrometry Proteomics Platform, The Francis Crick Institute, London, UK.ORCID 0000-0001-7002-9130
Marcus BantscheffCellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, 69117 Heidelberg, Germany.ORCID 0000-0002-8343-8977
Carla PasquarelloProteomics Core Facility, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.
Abigail J PerrinMalaria Biochemistry Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0001-6682-4297
Lorenzo BrusiniDepartment of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.ORCID 0000-0002-7080-566X
Patrizia ArboitProteomics Core Facility, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.
Olalla SanzDiseases of the Developing World Global Health Pharma Unit, GlaxoSmithKline, 28760 Tres Cantos, Spain.ORCID 0000-0003-3649-3460
Laura Peces-Barba CastañoMalaria Biochemistry Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0001-9026-5405
Chrislaine Withers-MartinezMalaria Biochemistry Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0003-1989-772X
Alexandre HainardProteomics Core Facility, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.
Sonja Ghidelli-DisseCellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, 69117 Heidelberg, Germany.ORCID 0000-0002-7735-9746
Ambrosius P SnijdersMass Spectrometry Proteomics Platform, The Francis Crick Institute, London, UK.ORCID 0000-0002-5416-8592
David A BakerFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.ORCID 0000-0002-5490-8933
Michael J BlackmanMalaria Biochemistry Laboratory, The Francis Crick Institute, London NW1 1AT, UK. konstantinos.kousis@crick.ac.uk mike.blackman@crick.ac.uk mathieu.brochet@unige.ch.ORCID 0000-0002-7442-3810
Mathieu BrochetDepartment of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland. konstantinos.kousis@crick.ac.uk mike.blackman@crick.ac.uk mathieu.brochet@unige.ch.ORCID 0000-0003-3911-5537
The Francis Crick Institute · GBUniversity of Geneva · CHGlaxoSmithKline (Germany) · DEUniversity of London · GBGlaxoSmithKline (Spain) · ES

Funding

Wellcome Trust FC001043
6 · The paper itself

Abstract

Calcium signaling regulated by the cGMP-dependent protein kinase (PKG) controls key life cycle transitions in the malaria parasite. However, how calcium is mobilized from intracellular stores in the absence of canonical calcium channels in

Indexed as

MalariaParasitesAnimalsCalciumCalcium ChannelsGametogenesisMembrane ProteinsPlasmodium bergheiProtozoan ProteinsCalciumCalcium ChannelsMembrane ProteinsProtozoan Proteins

Identifiers

PMID33762339
PMCPMC7990342
OpenAlexW3136418919

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.