Evidence map›Paper›PMID 33763450›Full record

ReviewFrontiers in molecular biosciences2021

Emerging Therapeutic Approaches to Combat COVID-19: Present Status and Future Perspectives.

Karthik Vivekanandhan, Poornima Shanmugam, Hamed Barabadi, Vigneshwaran Arumugam, Dharun Daniel Raj Daniel Paul Raj, Manikandan Sivasubramanian, Subbaiya Ramasamy, Krishnan Anand, Pandi Boomi, Balakumar Chandrasekaran and 2 more

Abstract readReview
In one paragraph

Review in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Evaluation of respiratory function among homemakers exposed to indoor air pollution.Journal of advanced pharmaceutical technology & research · 2022
    Article
  9. Article
  10. Review
  11. Current clinical status of new COVID-19 vaccines and immunotherapy.Environmental science and pollution research international · 2022
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Effect ofBioinformation · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Karthik VivekanandhanDepartment of Biotechnology, K. S. Rangasamy College of Technology, Tiruchengode, Tamilnadu, India.
Poornima ShanmugamDepartment of Biotechnology, K. S. Rangasamy College of Technology, Tiruchengode, Tamilnadu, India.
Hamed BarabadiDepartment of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Vigneshwaran ArumugamSchool of Biosciences and Technology, Vellore Institute of Technology, Vellore, India.
Dharun Daniel Raj Daniel Paul RajDepartment of Biotechnology, Maulana Abul Kalam Azad University of Technology, Haringhata, India.
Manikandan SivasubramanianDepartment of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India.
Subbaiya RamasamyDepartment of Biological Sciences, School of Mathematics and Natural Sciences, The Copperbelt University, Riverside, Zambia.
Krishnan AnandDepartment of Chemical Pathology, School of Pathology, Faculty of Health Sciences and National Health Laboratory Service, University of the Free State, Bloemfontein, South Africa.
Pandi BoomiDepartment of Bioinformatics, Alagappa University, Karaikudi, India.
Balakumar ChandrasekaranFaculty of Pharmacy, Philadelphia University, Amman, Jordan.
Selvaraj ArokiyarajDepartment of Food Science and Biotechnology, Sejong University, Seoul, South Korea.
Muthupandian SaravananDepartment of Microbiology and Immunology, Division of Biomedical Science, School of Medicine, College of Health Science, Mekelle University, Mekelle, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease (COVID-19) has emerged as a fast-paced epidemic in late 2019 which is disrupting life-saving immunization services. SARS-CoV-2 is a highly transmissible virus and an infectious disease that has caused fear among people across the world. The worldwide emergence and rapid expansion of SARS-CoV-2 emphasizes the need for exploring innovative therapeutic approaches to combat SARS-CoV-2. The efficacy of some antiviral drugs such as remdesivir, favipiravir, umifenovir, etc., are still tested against SARS-CoV-2. Additionally, there is a large global effort to develop vaccines for the protection against COVID-19. Because vaccines seem the best solution to control the pandemic but time is required for its development, pre-clinical/clinical trials, approval from FDA and scale-up. The nano-based approach is another promising approach to combat COVID-19 owing to unique physicochemical properties of nanomaterials. Peptide based vaccines emerged as promising vaccine candidates for SARS-CoV-2. The study emphasizes the current therapeutic approaches against SARS-CoV-2 and some of the potential candidates for SARS-CoV-2 treatment which are still under clinical studies for their effectiveness against SARS-CoV-2. Overall, it is of high importance to mention that clinical trials are necessary for confirming promising drug candidates and effective vaccines and the safety profile of the new components must be evaluated before translation of

Indexed as

antiviral drugsCOVID-19nano-based approachesSARS-CoV-2therapeuticsvaccines

Identifiers

PMID33763450
PMCPMC7983051

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.