ArticleThe Plant cell2021
Genome-wide signatures of plastid-nuclear coevolution point to repeated perturbations of plastid proteostasis systems across angiosperms.
Article in The Plant cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 50 citations in OpenAlex.
- Silene, a versatile model system: from sex and genome evolution to ecology and speciation.The New phytologist · 2026Review
- Coordinated Evolutionary Rates in Oxidative Phosphorylation Complexes of Papilionoid Legumes: Cytonuclear Coevolution and Relaxed Selection.bioRxiv : the preprint server for biology · 2026Article
- Sensitivity of genome-wide tests for mitonuclear genetic incompatibilities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Correlated Evolutionary Rates Reveal Novel Components and Cross-Compartment Connectivity in Plant Proteostasis Systems.Genome biology and evolution · 2026Article
- Comparative analysis of morphology and chloroplast genomes in endangered plantFrontiers in plant science · 2026Article
- Patterns of plastid gene evolution: identifying candidate genes for plastid-nuclear incompatibility across the Campanulaceae.Frontiers in plant science · 2026Article
- Plant MutS2 proteins function in plastid ribosome quality control.bioRxiv : the preprint server for biology · 2025Article
- ERC2.0 evolutionary rate covariation update improves inference of functional interactions across large phylogenies.Genome research · 2025Article
- ERCnet: Phylogenomic Prediction of Interaction Networks in the Presence of Gene Duplication.Molecular biology and evolution · 2025Article
- ERC 2.0 - evolutionary rate covariation update improves inference of functional interactions across large phylogenies.bioRxiv : the preprint server for biology · 2025Article
- Cytonuclear evolution in fully heterotrophic plants: lifestyles and gene function determine scenarios.BMC plant biology · 2024Article
- From light into shadow: comparative plastomes in Petrocosmea and implications for low light adaptation.BMC plant biology · 2024Article
- A cargo sorting receptor mediates chloroplast protein trafficking through the secretory pathway.The Plant cell · 2024Article
- Endosymbioses Have Shaped the Evolution of Biological Diversity and Complexity Time and Time Again.Genome biology and evolution · 2024Review
- Polyploid plants take cytonuclear perturbations in stride.The Plant cell · 2024Article
- Conservation Mitonuclear Replacement: Facilitated mitochondrial adaptation for a changing world.Evolutionary applications · 2024Article
- Co-evolution of gene transfer agents and their alphaproteobacterial hosts.Journal of bacteriology · 2024Article
- Association Analysis Provides Insights into Plant Mitonuclear Interactions.Molecular biology and evolution · 2024Article
- Distinctive plastome evolution in carnivorous angiosperms.BMC plant biology · 2023Article
- Evolution of the Araliaceae family involved rapid diversification of the Asian Palmate group and Hydrocotyle specific mutational pressure.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Nuclear and plastid (chloroplast) genomes experience different mutation rates, levels of selection, and transmission modes, yet key cellular functions depend on their coordinated interactions. Functionally related proteins often show correlated changes in rates of sequence evolution across a phylogeny [evolutionary rate covariation (ERC)], offering a means to detect previously unidentified suites of coevolving and cofunctional genes. We performed phylogenomic analyses across angiosperm diversity, scanning the nuclear genome for genes that exhibit ERC with plastid genes. As expected, the strongest hits were highly enriched for genes encoding plastid-targeted proteins, providing evidence that cytonuclear interactions affect rates of molecular evolution at genome-wide scales. Many identified nuclear genes functioned in post-transcriptional regulation and the maintenance of protein homeostasis (proteostasis), including protein translation (in both the plastid and cytosol), import, quality control, and turnover. We also identified nuclear genes that exhibit strong signatures of coevolution with the plastid genome, but their encoded proteins lack organellar-targeting annotations, making them candidates for having previously undescribed roles in plastids. In sum, our genome-wide analyses reveal that plastid-nuclear coevolution extends beyond the intimate molecular interactions within chloroplast enzyme complexes and may be driven by frequent rewiring of the machinery responsible for maintenance of plastid proteostasis in angiosperms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.