← Metformin × adverse events & safety

SynthesisThe Cochrane database of systematic reviews2021

Pharmacological and non-pharmacological strategies for obese women with subfertility.

Seyed Abdolvahab Taghavi et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 918 people · 2021

Randomised comparison

Probably raised pregnancy & neonatal

5.6×2.6× to 12×

Bigger than almost all on the map

As reported

OR 5.56, 95% CI 2.57–12.0

Range includes no effect

No clear effect on pregnancy & neonatal

1.5×1× to 2.4×

Bigger than 7 in 10 on the map

As reported

OR 1.54, 95% CI 0.99–2.39

Range includes no effect

No clear effect on pregnancy & neonatal

+6%−19% to +40%

Bigger than 1 in 10 on the map

As reported

OR 1.06, 95% CI 0.81–1.40

Range includes no effect

No clear effect on adverse events & safety

7.2×0.7× to 73×

Bigger than almost all for adverse events & safety

As reported

OR 7.22, 95% CI 0.72–72.7

+6 more in the walkthrough ↓

Ten numbers in the abstract

the abstract, start to end

… affects miscarriage rate (OR 1.54, 95% CI 0.99 to 2.39; 917 …

… affects clinical pregnancy (OR 1.06, 95% CI 0.81 to 1.40; 917 …

… effect on the adverse events nausea (OR 7.22, 95% CI 0.72 to 72.7; 28 women, 1 study; very low-quality evidence), diarrhoea (OR 0.31, 95% CI 0.01 to 8.3; 28 women, 1 study; very low-quality evidence), and headache (OR 5.80, 95% CI 0.25 to 133; 28 women, …

… of an effect on miscarriage (OR 3.58, 95% CI 0.73 to 17.55; 274 women, 1 study; very low-quality evidence), clinical pregnancy (OR 5.56, 95% CI 2.57 to 12.02; 274 …

… gastrointestinal adverse events (OR 0.91, 95% CI 0.32 to 2.57; 65 women, 1 study; very low-quality evidence) or miscarriage (OR 0.50, 95% CI 0.04 to 5.80; 65 women, 1 study; very low-quality evidence) or clinical pregnancy (OR 2.67, 95% CI 0.90 to 7.93; 96 women, …

← favours treatmentfavours comparator →
could be chance
Pregnancy & neonatal
OR 1.540.99–2.39
Pregnancy & neonatal
OR 1.060.81–1.40
Adverse events & safety
OR 7.220.72–72.7
Adverse events & safety
OR 0.310.01–8.30
Adverse events & safety
OR 5.800.25–133
Pregnancy & neonatal
OR 3.580.73–17.6
Pregnancy & neonatal
OR 5.562.57–12.0
Adverse events & safety
OR 0.910.32–2.57
Adverse events & safety
OR 0.500.04–5.80
Adverse events & safety
OR 2.670.90–7.93
MetforminGLP-1 receptor agonistsSupplements & botanicalsDiet, exercise & lifestylePregnancy & neonatalAdverse events & safety

Metformin × adverse events & safetyharms?mixed

unlikelylikely
0.27not counted

GLP-1 receptor agonists × adverse events & safetyharms?mixed

unlikelylikely
0.02not counted

Metformin × pregnancy & neonatalhelps?mixed

unlikelylikely
0.00not counted
← favours treatmentfavours comparator →
more certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 33765343