ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2022
Neuroanatomical Correlates Underlying the Association Between Maternal Interleukin 6 Concentration During Pregnancy and Offspring Fluid Reasoning Performance in Early Childhood.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- The association between maternal immune activation and brain structure and function in human offspring: a systematic review.Molecular psychiatry · 2025Pooled it
- The Earliest Impressions: A Systematic Review of Early-Life Exposures on Brain Structure and Neurodevelopmental Outcomes.bioRxiv : the preprint server for biology · 2026Article
- Maternal immune activation during gestation modulates offspring immune profiles in a nonhuman primate model.Brain, behavior, and immunity · 2026Article
- Fractal analysis of brain shape formation predicts age and genetic similarity in human newborns.Nature neuroscience · 2026Article
- Investigating the impact of severe maternal SARS-CoV-2 infection on infant DNA methylation and neurodevelopment.Molecular psychiatry · 2025Article
- Maternal Immune Activation and Child Brain Development: A Longitudinal Population-Based Multimodal Neuroimaging Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Prenatal maternal stress in rats alters the epigenetic and transcriptomic landscape of the maternal-fetal interface across four generations.Communications biology · 2025Article
- Maternal prenatal immune activation associated with brain tissue microstructure and metabolite concentrations in newborn infants.Brain, behavior, and immunity · 2024Article
- Prenatal maternal immune activation predicts observed fearfulness in infancy.Developmental psychology · 2024Article
- Examining longitudinal associations between prenatal exposure to infections and child brain morphology.Brain, behavior, and immunity · 2024Article
- Placental inflammatory cytokines mRNA expression and preschool children's cognitive performance: a birth cohort study in China.BMC medicine · 2023Article
- Long-term effects of prenatal infection on the human brain: a prospective multimodal neuroimaging study.Translational psychiatry · 2023Article
- Acute IL-6 exposure triggers canonical IL6Ra signaling in hiPSC microglia, but not neural progenitor cells.Brain, behavior, and immunity · 2023Article
- Maternal Immune Activation Hypotheses for Human Neurodevelopment: Some Outstanding Questions.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Review
- Maternal prenatal infection and anxiety predict neurodevelopmental outcomes in middle childhood.Journal of psychopathology and clinical science · 2022Article
- Interferon-γ exposure of human iPSC-derived neurons alters major histocompatibility complex I and synapsin protein expression.Frontiers in psychiatry · 2022Article
- Maternal Immune Activation during Pregnancy Alters Postnatal Brain Growth and Cognitive Development in Nonhuman Primate Offspring.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundMaternal inflammation during pregnancy can alter offspring brain development and influence risk for disorders commonly accompanied by deficits in cognitive functioning. We therefore examined associations between maternal interleukin 6 (IL-6) concentrations during pregnancy and offspring cognitive ability and concurrent magnetic resonance imaging-based measures of brain anatomy in early childhood. We further examined newborn brain anatomy in secondary analyses to consider whether effects are evident soon after birth and to increase capacity to differentiate effects of pre- versus postnatal exposures.
methodsIL-6 concentrations were quantified in early (12.6 ± 2.8 weeks), mid (20.4 ± 1.5 weeks), and late (30.3 ± 1.3 weeks) pregnancy. Offspring nonverbal fluid intelligence (Gf) was assessed at 5.2 ± 0.6 years using a spatial reasoning task (Wechsler Preschool and Primary Scale of Intelligence-Matrix) (n = 49). T1-weighted magnetic resonance imaging scans were acquired at birth (n = 89, postmenstrual age = 42.9 ± 2.0 weeks) and in early childhood (n = 42, scan age = 5.1 ± 1.0 years). Regional cortical volumes were examined for a joint association between maternal IL-6 and offspring Gf performance.
resultsAverage maternal IL-6 concentration during pregnancy was inversely associated with offspring Gf performance after adjusting for socioeconomic status and the quality of the caregiving and learning environment (R
conclusionsThese findings suggest that the origins of variation in child cognitive ability can, in part, trace back to maternal conditions during the intrauterine period of life and support the role of inflammation as an important component of this putative biological pathway.
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