ArticleNature communications2021
Clonal analysis and dynamic imaging identify multipotency of individual Gallus gallus caudal hindbrain neural crest cells toward cardiac and enteric fates.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Regulatory logic underlying neural crest contributions to the head versus the heart.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Single-cell omics uncovers novel pathological mechanisms and therapeutic targets for congenital heart diseases: insights from integrated intercellular communication analysis.Stem cell research & therapy · 2026Review
- Unbiased profiling of multipotency landscapes reveals spatial modulators of clonal fate biases.bioRxiv : the preprint server for biology · 2025Article
- BMP signaling pathway member expression is enriched in enteric neural progenitors and required for zebrafish enteric nervous system development.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- Epithelial-mesenchymal transition in tissue repair and degeneration.Nature reviews. Molecular cell biology · 2024Review
- A time-resolved single-cell roadmap of the logic driving anterior neural crest diversification from neural border to migration stages.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The origin, evolution, and molecular diversity of the chemokine system.Life science alliance · 2024Article
- Genetic regulation of enteric nervous system development in zebrafish.Biochemical Society transactions · 2024Review
- Article
- CXCR4 and CXCL12 signaling regulates the development of extrinsic innervation to the colorectum.Development (Cambridge, England) · 2023Article
- Reassessing the embryonic origin and potential of craniofacial ectomesenchyme.Seminars in cell & developmental biology · 2023Review
- The transcriptional portraits of the neural crest at the individual cell level.Seminars in cell & developmental biology · 2023Review
- RA signaling pathway combined with Wnt signaling pathway regulates human-induced pluripotent stem cells (hiPSCs) differentiation to sinus node-like cells.Stem cell research & therapy · 2022Article
- Elevated Hoxb5b Expands Vagal Neural Crest Pool and Blocks Enteric Neuronal Development in Zebrafish.Frontiers in cell and developmental biology · 2021Article
- Shared and individual expression patterns of pluripotency genes in the developing chick embryo during neurulation and beyond.Differentiation; research in biological diversityArticle
- Enteric neural crest development in Astyanax mexicanus surface fish and cavefish.Differentiation; research in biological diversityArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural crest stem cells arising from caudal hindbrain (often called cardiac and posterior vagal neural crest) migrate long distances to form cell types as diverse as heart muscle and enteric ganglia, abnormalities of which lead to common congenital birth defects. Here, we explore whether individual caudal hindbrain neural crest precursors are multipotent or predetermined toward these particular fates and destinations. To this end, we perform lineage tracing of chick neural crest cells at single-cell resolution using two complementary approaches: retrovirally mediated multiplex clonal analysis and single-cell photoconversion. Both methods show that the majority of these neural crest precursors are multipotent with many clones producing mesenchymal as well as neuronal derivatives. Time-lapse imaging demonstrates that sister cells can migrate in distinct directions, suggesting stochasticity in choice of migration path. Perturbation experiments further identify guidance cues acting on cells in the pharyngeal junction that can influence this choice; loss of CXCR4 signaling results in failure to migrate to the heart but no influence on migration toward the foregut, whereas loss of RET signaling does the opposite. Taken together, the results suggest that environmental influences rather than intrinsic information govern cell fate choice of multipotent caudal hindbrain neural crest cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.