Evidence map›Paper›PMID 33767430›Full record

ArticleCommunications biology2021

Vitamin D upregulates the macrophage complement receptor immunoglobulin in innate immunity to microbial pathogens.

Annabelle G Small, Sarah Harvey, Jaspreet Kaur, Trishni Putty, Alex Quach, Usma Munawara, Khalida Perveen, Andrew McPhee, Charles S Hii, Antonio Ferrante

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Vitamin DFrontiers in immunology · 2026
    Review
  7. Review
  8. Review
  9. Effects of vitamin DBiology of sport · 2025
    Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Vitamin D and allergic diseases.Frontiers in immunology · 2024
    Review
  16. Observational
  17. Observational
  18. How Does Vitamin D Affect Immune Cells Crosstalk in Autoimmune Diseases?International journal of molecular sciences · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Annabelle G SmallDepartment of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide, Australia.ORCID 0000-0001-6275-2847
Sarah HarveyDepartment of Immunopathology, SA Pathology, Women's and Children's Hospital, Adelaide, Australia.
Jaspreet KaurDepartment of Immunopathology, SA Pathology, Women's and Children's Hospital, Adelaide, Australia.
Trishni PuttyThe Robinson Research Institute and School of Medicine, University of Adelaide, Adelaide, Australia.
Alex QuachThe Robinson Research Institute and School of Medicine, University of Adelaide, Adelaide, Australia.ORCID 0000-0003-1912-7581
Usma MunawaraThe Robinson Research Institute and School of Medicine, University of Adelaide, Adelaide, Australia.
Khalida PerveenDepartment of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide, Australia.ORCID 0000-0002-1499-1736
Andrew McPheeDepartment of Neonatal Medicine, Women's and Children's Hospital, Adelaide, South Australia.
Charles S HiiThe Robinson Research Institute and School of Medicine, University of Adelaide, Adelaide, Australia.
Antonio FerranteDepartment of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide, Australia. antonio.ferrante@adelaide.edu.au.ORCID 0000-0002-2581-6407
South Australia Pathology · AUWomen's and Children's Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D deficiency remains a global concern. This 'sunshine' vitamin is converted through a multistep process to active 1,25-dihydroxyvitamin D

Indexed as

CalcitriolImmunity, InnateImmunoglobulinsMacrophagesReceptors, Complement 3bUp-RegulationCalcitriolCR1 protein, humanImmunoglobulinsReceptors, Complement 3b

Identifiers

PMID33767430
PMCPMC7994403
OpenAlexW3137033683

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.