Evidence map›Paper›PMID 33767668›Full record

ArticleFrontiers in endocrinology2021

Shiuhwei Chen, ZhiJiang Huang, Harrison Kidd, Min Kim, Eul Hyun Suh, Shangkui Xie, Ebrahim H Ghazvini Zadeh, Yan Xu, A Dean Sherry, Philipp E Scherer and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Apollo-NADPScience advances · 2023
    Article
  7. Review
  8. Review
  9. Sequential in vivo labeling of insulin secretory granule pools inProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Shiuhwei ChenDepartments of Cell Biology and of Biochemistry, University of Texas Southwestern Medical, Dallas, TX, United States.
ZhiJiang HuangDepartments of Cell Biology and of Biochemistry, University of Texas Southwestern Medical, Dallas, TX, United States.
Harrison KiddDepartments of Cell Biology and of Biochemistry, University of Texas Southwestern Medical, Dallas, TX, United States.
Min KimTouchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Eul Hyun SuhAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Shangkui XieDepartments of Cell Biology and of Biochemistry, University of Texas Southwestern Medical, Dallas, TX, United States.
Ebrahim H Ghazvini ZadehDepartments of Cell Biology and of Biochemistry, University of Texas Southwestern Medical, Dallas, TX, United States.
Yan XuDepartments of Cell Biology and of Biochemistry, University of Texas Southwestern Medical, Dallas, TX, United States.
A Dean SherryAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Philipp E SchererTouchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Wen-Hong LiDepartments of Cell Biology and of Biochemistry, University of Texas Southwestern Medical, Dallas, TX, United States.
The University of Texas Southwestern Medical Center · USUlsan National Institute of Science and Technology · KR

Funding

White Adipose Tissue Physiology, Mitochondrial Function and AdiponectinR01DK099110 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI PHILIPP E SCHERER · 2013 to 2026
$6.7M
Imaging Beta Cell Function in Vivo with Zinc Responsive MRI Contrast AgentsR01DK095416 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI SHERRY, DEAN · 2012 to 2021
$3.3M
Request for Administrative Supplement to GM132610 entitled "Probes and techniques for biological imaging applications"R01GM132610 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI LI, WEN-HONG · 2019 to 2022
$2.2M
NIDDK NIH HHS R01 DK095416NIDDK NIH HHS R01 DK099110NIGMS NIH HHS R01 GM132610
6 · The paper itself

Abstract

Appropriate insulin secretion is essential for maintaining euglycemia, and impairment or loss of insulin release represents a causal event leading to diabetes. There have been extensive efforts of studying insulin secretion and its regulation using a variety of biological preparations, yet it remains challenging to monitor the dynamics of insulin secretion at the cellular level in the intact pancreas of living animals, where islet cells are supplied with physiological blood circulation and oxygenation, nerve innervation, and tissue support of surrounding exocrine cells. Herein we presented our pilot efforts of ZIMIR imaging in pancreatic islet cells in a living mouse. The imaging tracked insulin/Zn

Indexed as

Insulin-Secreting CellsInsulin SecretionAnimalsBiological ClocksBiomarkersCytoplasmic GranulesExocytosisFluorescenceHEK293 CellsHumansIslets of LangerhansMiceMice, Inbred C57BLMice, TransgenicMolecular ImagingOptical ImagingBiomarkersZincbeta cell imagingbeta cell massHaloTagimaging insulin secretioninsulin oscillationintravital microscopy (IVM)ZIGIRZIMIR

Identifiers

PMID33767668
PMCPMC7985533
OpenAlexW3133602332

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.