Evidence map›Paper›PMID 33767672›Full record

ArticleFrontiers in endocrinology2021

Sperm DNA Methylation at Metabolism-Related Genes in Vegan Subjects.

Marica Franzago, Iva Sabovic, Sara Franchi, Maria De Santo, Andrea Di Nisio, Alice Luddi, Paola Piomboni, Ester Vitacolonna, Liborio Stuppia, Carlo Foresta

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. How Food Choices Impact on Male Fertility.Current nutrition reports · 2023
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Marica FranzagoDepartment of Medicine and Aging, School of Medicine and Health Sciences, "G. D'Annunzio" University, Chieti-Pescara, Chieti, Italy.
Iva SabovicUnit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, Padova, Italy.
Sara FranchiCenter for Advanced Studies and Technology (CAST), "G. D'Annunzio" University, Chieti-Pescara, Chieti, Italy.
Maria De SantoCasa di Cura Privata Spatocco, Chieti, Italy.
Andrea Di NisioUnit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, Padova, Italy.
Alice LuddiDepartment of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
Paola PiomboniDepartment of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
Ester VitacolonnaDepartment of Medicine and Aging, School of Medicine and Health Sciences, "G. D'Annunzio" University, Chieti-Pescara, Chieti, Italy.
Liborio StuppiaCenter for Advanced Studies and Technology (CAST), "G. D'Annunzio" University, Chieti-Pescara, Chieti, Italy.
Carlo ForestaUnit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, Padova, Italy.
University of Chieti-Pescara · ITUniversity of Padua · ITUniversity of Siena · ITCasa di Cura Villa Pini d’Abruzzo · ITUniversity of Brescia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate if epigenome of sperm cells could be dynamically affected by nutrition. Design and Methods: We assessed 40 healthy volunteers with different dietary habits and collected their demographic characteristics, as well as clinical and anthropometric parameters. We compared methylation profiles in sperm quantified by bisulfite pyrosequencing, at promoter-associated CpG sites of genes involved in metabolism including fat mass and obesity-associated ( Results: Higher DNA methylation levels were detected in the sperm of vegan at Conclusions: Although limited by the small number of investigated cases, our data provide insight into the role of diet on sperm DNA methylation in genes involved in metabolism.

Indexed as

Diet, VeganDNA MethylationAdultAlpha-Ketoglutarate-Dependent Dioxygenase FTOAnthropometryCpG IslandsEpigenesis, GeneticGenotypeHealthy VolunteersHumansMaleMiddle AgedNutritional SciencesPromoter Regions, GeneticReceptor, Melanocortin, Type 4SpermatozoaAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanMC4R protein, humanReceptor, Melanocortin, Type 4epigeneticnutritionreproductionspermvegan

Identifiers

PMID33767672
PMCPMC7985526
OpenAlexW3134781728

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.