Evidence map›Paper›PMID 33770503›Full record

ArticleStructure (London, England : 1993)2021

Na

Ryan Mahling, Liam Hovey, Holly M Isbell, Dagan C Marx, Mark S Miller, Adina M Kilpatrick, Lisa D Weaver, Jesse B Yoder, Elaine H Kim, Corinne N J Andresen and 2 more

Open access · greenAbstract read
In one paragraph

Article in Structure (London, England : 1993), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Physiologically Relevant Free CaJournal of molecular biology · 2021
    Article
  6. Calmodulin Interactions with Voltage-Gated Sodium Channels.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ryan MahlingDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA.
Liam HoveyDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA.
Holly M IsbellDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA.
Dagan C MarxDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA.
Mark S MillerDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA.
Adina M KilpatrickDepartment of Physics and Astronomy, Drake University, Des Moines, IA 50311-4516, USA.
Lisa D WeaverDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA.
Jesse B YoderDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA.
Elaine H KimDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA.
Corinne N J AndresenDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA.
Shuxiang LiDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA.
Madeline A SheaDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242-1109, USA. Electronic address: madeline-shea@uiowa.edu.
University of Iowa · USDrake University · US

Funding

PREDOCTORAL TRAINING PROGRAM IN BIOTECHNOLOGYT32GM008365 · NIGMS · UNIVERSITY OF IOWA · PI KERNS, ROBERT JOHN · 1990 to 2021
$3.8M
Interdisciplinary Training Program in Pain ResearchT32NS045549 · NINDS · UNIVERSITY OF IOWA · PI KATHLEEN A SLUKA, Yuriy M Usachev · 2004 to 2026
$3.7M
MOLECULAR DISSECTION OF CALMODULIN DOMAIN INTERACTIONSR01GM057001 · NIGMS · UNIVERSITY OF IOWA · PI SHEA, MADELINE A · 1998 to 2015
$2.9M
NIGMS NIH HHS R01 GM057001NIGMS NIH HHS T32 GM008365NINDS NIH HHS T32 NS045549
6 · The paper itself

Abstract

Neuronal voltage-gated sodium channel Na

Indexed as

CalciumCalcium SignalingCalmodulinHumansMutationNAV1.2 Voltage-Gated Sodium ChannelProtein BindingCalciumCalmodulinNAV1.2 Voltage-Gated Sodium Channelaffinityallosterybindingbiosensorfree energyFRETlinkagemolecular recognitionNMRtitrationvoltage-gated sodium channel

Identifiers

PMID33770503
PMCPMC8458505
OpenAlexW3136891117

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.