Evidence map›Paper›PMID 33771413›Full record

ArticleAnnals of emergency medicine2021

Diagnosed and Undiagnosed COVID-19 in US Emergency Department Health Care Personnel: A Cross-sectional Analysis.

Nicholas M Mohr, Karisa K Harland, Anusha Krishnadasan, Patrick Ten Eyck, William R Mower, James Willey, Makini Chisolm-Straker, Stephen C Lim, L Clifford McDonald, Preeta K Kutty and 4 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of emergency medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  9. Article
  10. Vaccination rates and acceptance of SARS-CoV-2 vaccination among U.S. emergency department health care personnel.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Nicholas M MohrDepartment of Emergency Medicine, University of Iowa Carver College of Medicine, Iowa City, IA. Electronic address: nicholas-mohr@uiowa.edu.
Karisa K HarlandDepartment of Emergency Medicine, University of Iowa Carver College of Medicine, Iowa City, IA.
Anusha KrishnadasanOlive View-UCLA Education and Research Institute, Los Angeles, CA.
Patrick Ten EyckInstitute for Clinical and Translational Science, University of Iowa Carver College of Medicine, Iowa City, IA.
William R MowerDepartment of Emergency Medicine, University of California-Los Angeles Ronald Reagan Medical Center, Los Angeles.
James WilleyDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA.
Makini Chisolm-StrakerDepartment of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Stephen C LimDepartment of Emergency Medicine, University Medical Center, New Orleans, LA.
L Clifford McDonaldDivision of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA.
Preeta K KuttyDivision of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA.
Elisabeth HesseDivision of Preparedness and Emerging Infections, Centers for Disease Control and Prevention, Atlanta, GA.
Scott SantibanezDivision of Preparedness and Emerging Infections, Centers for Disease Control and Prevention, Atlanta, GA.
David A TalanDepartment of Emergency Medicine, University of Iowa Carver College of Medicine, Iowa City, IA; Olive View-UCLA Education and Research Institute, Los Angeles, CA; Department of Emergency Medicine, University of California-Los Angeles Ronald Reagan Medical Center, Los Angeles.
Project COVERED Emergency Department Network
University of Iowa · USCenters for Disease Control and Prevention · USEducation and Research Institute · USIcahn School of Medicine at Mount Sinai · USUniversity Medical Center New Orleans · USUniversity of California, Los Angeles · US

Funding

The University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0M
NCATS NIH HHS UL1 TR002537NCEZID CDC HHS U01 CK000480
6 · The paper itself

Abstract

STUDY

objectiveWe determine the percentage of diagnosed and undiagnosed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among a sample of US emergency department (ED) health care personnel before July 2020.

methodsThis was a cross-sectional analysis of ED health care personnel in 20 geographically diverse university-affiliated EDs from May 13, to July 8, 2020, including case counts of prior laboratory-confirmed coronavirus disease 2019 (COVID-19) diagnoses among all ED health care personnel, and then point-in-time serology (with confirmatory testing) and reverse transcriptase-polymerase chain reaction testing in a sample of volunteers without a previous COVID-19 diagnosis. Health care staff were categorized as clinical (physicians, advanced practice providers, and nurses) and nonclinical (clerks, social workers, and case managers). Previously undiagnosed infection was based on positive SARS-CoV-2 serology or reverse transcriptase-polymerase chain reaction result among health care personnel without prior diagnosis.

resultsDiagnosed COVID-19 occurred in 2.8% of health care personnel (193/6,788), and the prevalence was similar for nonclinical and clinical staff (3.8% versus 2.7%; odds ratio 1.5; 95% confidence interval 0.7 to 3.2). Among 1,606 health care personnel without previously diagnosed COVID-19, 29 (1.8%) had evidence of current or past SARS-CoV-2 infection. Most (62%; 18/29) who were seropositive did not think they had been infected, 76% (19/25) recalled COVID-19-compatible symptoms, and 89% (17/19) continued to work while symptomatic. Accounting for both diagnosed and undiagnosed infections, 4.6% (95% confidence interval 2.8% to 7.5%) of ED health care personnel were estimated to have been infected with SARS-CoV-2, with 38% of those infections undiagnosed.

conclusionIn late spring and early summer 2020, the estimated prevalence of severe acute respiratory syndrome coronavirus 2 infection was 4.6%, and greater than one third of infections were undiagnosed. Undiagnosed SARS-CoV-2 infection may pose substantial risk for transmission to other staff and patients.

Indexed as

SARS-CoV-2AdultCOVID-19Cross-Sectional StudiesEmergency Service, HospitalFemaleHealth PersonnelHospitals, UniversityHumansMaleMiddle AgedPrevalenceUnited States

Identifiers

PMID33771413
PMCPMC7746085
OpenAlexW3111959028

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.