Evidence map›Paper›PMID 33771508›Full record

ArticleArchives of biochemistry and biophysics2021

Disease variants of human Δ

Sagar M Patel, Javier Seravalli, Xinwen Liang, John J Tanner, Donald F Becker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of biochemistry and biophysics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. [Research Progress on the Role and Mechanisms of PYCR1 
in Tumorigenesis and Progression].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Expression and kinetic characterization of PYCR3.Archives of biochemistry and biophysics · 2023
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. The Multifaceted Roles of Proline in Cell Behavior.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sagar M PatelDepartment of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Javier SeravalliDepartment of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Xinwen LiangDepartment of Pediatrics, Penn State College of Medicine, Hershey, PA, 17033, USA.
John J TannerDepartments of Biochemistry and Chemistry, University of Missouri, Columbia, MO, 65211, USA.
Donald F BeckerDepartment of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA. Electronic address: dbecker3@unl.edu.
University of Nebraska–Lincoln · USPenn State Milton S. Hershey Medical Center · USUniversity of Missouri · US

Funding

Substrate Channeling and Communication in Proline Metabolic EnzymesR01GM065546 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI Donald F Becker, JOHN J TANNER · 2002 to 2026
$5.0M
Investigating the Proline Cycle as a Potential Cancer Therapy TargetR01GM132640 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI Donald F Becker, JOHN J TANNER · 2020 to 2026
$1.9M
NIGMS NIH HHS R01 GM065546NIGMS NIH HHS R01 GM132640
6 · The paper itself

Abstract

Pyrroline-5-carboxylate reductase (PYCR in humans) catalyzes the final step of l-proline biosynthesis by catalyzing the reduction of L-Δ

Indexed as

Mutationdelta-1-Pyrroline-5-Carboxylate ReductaseDiseaseEnzyme StabilityHumansKineticsProtein Structure, SecondaryPyrroline Carboxylate ReductasesTemperaturedelta-1-Pyrroline-5-Carboxylate ReductasePYCR2 protein, humanPyrroline Carboxylate ReductasesCircular dichroismProduct inhibition kineticsProline biosynthesisProtein thermostabilitySteady-state kineticsSubstrate-binding orderΔ(1)-pyrroline-5-carboxylate reductase

Identifiers

PMID33771508
PMCPMC8120637
OpenAlexW3137720997

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.