Evidence map›Paper›PMID 33775109›Full record

ArticleJournal of the American Heart Association2021

Effects of Post-Resuscitation Normoxic Therapy on Oxygen-Sensitive Oxidative Stress in a Rat Model of Cardiac Arrest.

Yu Okuma, Lance B Becker, Kei Hayashida, Tomoaki Aoki, Kota Saeki, Mitsuaki Nishikimi, Muhammad Shoaib, Santiago J Miyara, Tai Yin, Koichiro Shinozaki

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yu OkumaThe Feinstein Institutes for Medical ResearchNorthwell Manhasset NY.
Lance B BeckerThe Feinstein Institutes for Medical ResearchNorthwell Manhasset NY.
Kei HayashidaThe Feinstein Institutes for Medical ResearchNorthwell Manhasset NY.
Tomoaki AokiThe Feinstein Institutes for Medical ResearchNorthwell Manhasset NY.
Kota SaekiThe Feinstein Institutes for Medical ResearchNorthwell Manhasset NY.
Mitsuaki NishikimiThe Feinstein Institutes for Medical ResearchNorthwell Manhasset NY.
Muhammad ShoaibThe Feinstein Institutes for Medical ResearchNorthwell Manhasset NY.
Santiago J MiyaraThe Feinstein Institutes for Medical ResearchNorthwell Manhasset NY.
Tai YinThe Feinstein Institutes for Medical ResearchNorthwell Manhasset NY.
Koichiro ShinozakiThe Feinstein Institutes for Medical ResearchNorthwell Manhasset NY.
Feinstein Institute for Medical Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Cardiac arrest (CA) can induce oxidative stress after resuscitation, which causes cellular and organ damage. We hypothesized that post-resuscitation normoxic therapy would protect organs against oxidative stress and improve oxygen metabolism and survival. We tested the oxygen-sensitive reactive oxygen species from mitochondria to determine the association with hyperoxia-induced oxidative stress. Methods and Results Sprague-Dawley rats were subjected to 10-minute asphyxia-induced CA with a fraction of inspired O

Indexed as

Oxidative StressAnimalsCardiopulmonary ResuscitationDisease Models, AnimalHeart ArrestMaleOxygenOxygen ConsumptionOxygen Inhalation TherapyRatsOxygenhyperoxiaischemic reperfusion injurymitochondrial dysfunctionoxidative stressoxygen consumption

Identifiers

PMID33775109
PMCPMC8174361
OpenAlexW3144544285

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.