Evidence map›Paper›PMID 33775111›Full record

Observational studyCirculation. Heart failure2021

Metabolically Healthy/Unhealthy Overweight/Obesity Associations With Incident Heart Failure in Postmenopausal Women: The Women's Health Initiative.

Amber R Cordola Hsu, Bin Xie, Darleen V Peterson, Michael J LaMonte, Lorena Garcia, Charles B Eaton, Scott B Going, Lawrence S Phillips, JoAnn E Manson, Hoda Anton-Culver and 2 more

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Circulation. Heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Amber R Cordola HsuHeart Disease Prevention Program, Division of Cardiology, Department of Medicine (A.R.C.H., N.D.W.), UC Irvine School of Medicine, University of California.
Bin XieSchool of Community and Global Health, Claremont Graduate University, The Claremont Colleges, CA (A.R.C.H., B.X., D.V.P.).
Darleen V PetersonSchool of Community and Global Health, Claremont Graduate University, The Claremont Colleges, CA (A.R.C.H., B.X., D.V.P.).
Michael J LaMonteSchool of Public Health and Health Professions, University of Buffalo, NY (M.J.L.).
Lorena GarciaDivision of Epidemiology, Department of Public Health Sciences, UC Davis School of Medicine, CA (L.G.).
Charles B EatonDepartments of Family Medicine and Epidemiology, Alpert Medical School and School of Public Health, Brown University, Pawtucket, RI (C.B.E.).
Scott B GoingDepartment of Nutritional Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson (S.B.G.).
Lawrence S PhillipsAtlanta VA Medical Center and Division of Endocrinology, Department of Medicine, Emory University, GA (L.S.P.).
JoAnn E MansonDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (J.E.M.).
Hoda Anton-Culver *Department of Medicine (H.A.-C.), UC Irvine School of Medicine, University of California.
Nathan D Wong *Heart Disease Prevention Program, Division of Cardiology, Department of Medicine (A.R.C.H., N.D.W.), UC Irvine School of Medicine, University of California.
WHI Investigators
Claremont Graduate University · USBrigham and Women's Hospital · USBrown University · USUniversity of California, Irvine · USAtlanta VA Medical Center · USDepartment of Public Health · USUniversity at Buffalo, State University of New York · USUniversity of Arizona · US

Funding

Continuation of the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) StudyU01DK098246 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI Heidi Krause-Steinrauf, JOHN M LACHIN · 2021 to 2022
$21.0M
Technologies Advancing Translation - Regional CoreP30DK111024 · EMORY UNIVERSITY · 2025 to 2025
$775k
BLRD VA I01 BX005831CSRD VA I01 CX001025CSRD VA I01 CX001737NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNIAID NIH HHS R03 AI133172NIDDK NIH HHS P30 DK111024NIDDK NIH HHS R21 DK099716NIDDK NIH HHS U01 DK098246NIDDK NIH HHS U34 DK091958
6 · The paper itself

Abstract

backgroundObesity is associated with an increased risk of heart failure (HF); however, how metabolic weight groups relate to HF risk, especially in postmenopausal women, has not been demonstrated.

methodsWe included 19 412 postmenopausal women ages 50 to 79 without cardiovascular disease from the Women's Health Initiative. Normal weight was defined as a body mass index ≥18.5 and <25 kg/m

resultsAmong our sample, 455 (2.34%) participants experienced HF hospitalizations over a mean follow-up time of 11.3±1.1 years. Compared with metabolically healthy normal weight individuals, HF risk was greater in metabolically unhealthy normal weight (HR, 1.66 [95% CI, 1.01-2.72],

conclusionsMetabolically unhealthy overweight/obese and metabolically unhealthy normal weight are associated with an increased risk of HF in postmenopausal women.

Indexed as

PostmenopauseAgedBody Mass IndexDiabetes MellitusFemaleHeart FailureHospitalizationHumansHypertensionIncidenceLipidsMiddle AgedObesityOverweightRisk AssessmentRisk FactorsLipidsdiabetesheart failureobesitypostmenopausewomen

Identifiers

PMID33775111
PMCPMC11978397
OpenAlexW3148333579

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.