Evidence map›Paper›PMID 33775113›Full record

ReviewHypertension (Dallas, Tex. : 1979)2021

Subtypes of Preeclampsia: Recognition and Determining Clinical Usefulness.

James M Roberts, Janet W Rich-Edwards, Thomas F McElrath, Lana Garmire, Leslie Myatt, Global Pregnancy Collaboration

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
  2. Biomarkers of endothelial glycocalyx dysfunction in pregnancy: a systematic review of clinical relevance and detection techniques.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Pooled it
  3. Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum.American journal of physiology. Heart and circulatory physiology · 2024
    Guideline
  4. Pooled it
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  10. Trial
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  13. Article
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  16. Review
  17. Phenotyping Preeclampsia Using Unsupervised Machine Learning: A Prospective Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026
    Article
  18. Article
  19. The pathophysiology of pre-eclampsia.Nature reviews. Nephrology · 2026
    Review
  20. Article

113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

James M RobertsMagee-Womens Research Institute, Department of Obstetrics Gynecology and Reproductive Sciences, Epidemiology and Clinical and Translational Research, University of Pittsburgh (J.M.R.).
Janet W Rich-EdwardsDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA (J.W.R.-E.).
Thomas F McElrathDivision of Maternal-Fetal Medicine (T.F.M.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Lana GarmireDepartment of Computational Medicine and Bioinformatics, Medical School, University of Michigan (L.G.).
Leslie MyattDepartment of Obstetrics and Gynecology, Moore Institute of Nutrition and Wellness, Oregon Health and Science University (L.M.).
Global Pregnancy Collaboration

Funding

An Integrative Omics Approach to Identify Biomarkers Related to Preeclampsia and Breast Cancer RisksR01HD084633 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARMIRE, LANA X · 2016 to 2020
$3.0M
Cancer precision medicine through spatially informative single cell image and transcriptomics data analysisR01LM012373 · NLM · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARMIRE, LANA X · 2016 to 2024
$2.4M
DR. EPS: Drug Repurposing for Extended Patient SurvivalR01LM012907 · NLM · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARMIRE, LANA X · 2019 to 2022
$1.0M
NICHD NIH HHS R01 HD084633NLM NIH HHS R01 LM012373NLM NIH HHS R01 LM012907
6 · The paper itself

Abstract

The concept that preeclampsia is a multisystemic syndrome is appreciated in both research and clinical care. Our understanding of pathophysiology recognizes the role of inflammation, oxidative and endoplasm reticulum stress, and angiogenic dysfunction. Yet, we have not progressed greatly toward clinically useful prediction nor had substantial success in prevention or treatment. One possibility is that the maternal syndrome may be reached through different pathophysiological pathways, that is, subtypes of preeclampsia, that in their specificity yield more clinical utility. For example, early and late onset preeclampsia are increasingly acknowledged as different pathophysiological processes leading to a common presentation. Other subtypes of preeclampsia are supported by disparate clinical outcomes, long-range prognosis, organ systems involved, and risk factors. These insights have been supplemented by discovery-driven methods, which cluster preeclampsia cases into groups indicating different pathophysiologies. In this presentation, we review likely subtypes based on current knowledge and suggest others. We present a consideration of the requirements for a clinically meaningful preeclampsia subtype. A useful subtype should (1) identify a specific pathophysiological pathway or (2) specifically indicate maternal or fetal outcome, (3) be recognizable in a clinically useful time frame, and (4) these results should be reproducible and generalizable (but at varying frequency) including in low resource settings. We recommend that the default consideration be that preeclampsia includes several subtypes rather than trying to force all cases into a single pathophysiological pathway. The recognition of subtypes and deciphering their different pathophysiologies will provide specific targets for prevention, prediction, and treatment directing personalized care.

Indexed as

FemaleHumansInflammationPre-EclampsiaPregnancyPrognosisRisk Factorsepidemiologyinflammationpredictionpreeclampsiasyndrome

Identifiers

PMID33775113
PMCPMC8103569

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.