Trial reportHypertension (Dallas, Tex. : 1979)2021
Effect of Intensive Blood Pressure Control on Aortic Stiffness in the SPRINT-HEART.
Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Mortality and Cardiovascular End Points In Relation to the Aortic Pulse Wave Components: An Individual-Participant Meta-Analysis.Hypertension (Dallas, Tex. : 1979) · 2024Pooled it
- Effect of Hypertension Duration on the Associations Between Intensive Blood Pressure Control and Cardiac, Vascular, and Kidney Organ Damage.Journal of the American Heart Association · 2026Trial
- Influence of baseline arterial stiffness on effects of intensive compared with standard blood pressure control: a post hoc analysis of the STEP trial.BMC medicine · 2022Trial
- The role of vascular aging, bone marrow and immune system in hypertension.Cell death discovery · 2026Review
- Polygenic Determinants of Arterial Stiffness: Implications for Hypertension.medRxiv : the preprint server for health sciences · 2025Article
- Association of Total Mortality and Cardiovascular Endpoints With the Timing of the First and Second Systolic Peak of the Aortic Pulse Wave.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Temporal relationship between arterial stiffness and blood pressure variability and joint effect on cardiovascular disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Intensive Systolic Blood Pressure Treatment Remodels Brain Perivascular Spaces: A Secondary Analysis of SPRINT.medRxiv : the preprint server for health sciences · 2023Article
- What Is the Smallest Change in Pulse Wave Velocity Measurements That Can Be Attributed to Clinical Changes in Arterial Stiffness with Certainty: A Randomized Cross-Over Study.Journal of cardiovascular development and disease · 2023Article
- Heart Failure Primary Prevention: What Does SPRINT Add?: Recent Advances in Hypertension.Hypertension (Dallas, Tex. : 1979) · 2021Review
- Non-invasive Systemic Hemodynamic Index in Vascular Risk Stratification Tailored for Hypertensives.Frontiers in cardiovascular medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 12 institutions in 1 country.
Bharathi UpadhyaCardiovascular Medicine Section (B.U., D.W.K.), Wake Forest School of Medicine, Winston-Salem, NC.
Nicholas M PajewskiDepartment of Biostatistics and Data Science (N.M.P.), Wake Forest School of Medicine, Winston-Salem, NC.
Michael V RoccoNephrology Section, Department of Internal Medicine (M.V.R.), Wake Forest School of Medicine, Winston-Salem, NC.
W Gregory HundleyPauley Heart Center Department of Internal Medicine at Virginia Commonwealth University Health Sciences Richmond (W.G.H.).
Gerard AurigemmaCardiovascular Medicine Section, University of Massachusetts Medical School, Worcester (G.A.).
Craig A HamiltonBiomedical Engineering (C.A.H.), Wake Forest School of Medicine, Winston-Salem, NC.
Jeffrey T BatesDepartment of Medicine, Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX (J.T.B., A.T.).
Jiang HeDivision of Nephrology & Hypertension, Tulane University School of Public Health and Tropical Medicine, Department of Medicine, Tulane University, New Orleans, LA (J.H., J.C.).
Jing ChenDivision of Nephrology & Hypertension, Tulane University School of Public Health and Tropical Medicine, Department of Medicine, Tulane University, New Orleans, LA (J.H., J.C.).
Michel ChoncholDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora (M.C.).
Steve P GlasserUAB School of Public Health, University of Alabama, Birmingham (S.P.G.).
Adriana M HungDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN (A.M.H.).
Roberto PisoniNephrology Section, Medical University of South Carolina, Ralph H. Johnson VA Medical Center, Charleston (R.P.).
Henry PunziInternal Medicine, Trinity Hypertension and Metabolic Research Institute, Punzi Medical Center, Carrollton, TX (H.P.).
Mark A SupianoGeriatrics Division, VA Salt Lake City Geriatric Research, Education, and Clinical Center, University of Utah School of Medicine University of Utah School of Medicine, Salt Lake City (M.A.S.).
Robert TotoNephrology Section, University of Texas Southwestern Medical Center, Dallas (R.T.).
Addison TaylorDepartment of Medicine, Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX (J.T.B., A.T.).
Dalane W KitzmanCardiovascular Medicine Section (B.U., D.W.K.), Wake Forest School of Medicine, Winston-Salem, NC.
SPRINT Research Group
Wake Forest University · USMichael E. DeBakey VA Medical Center · USTulane University · USAlabama Department of Public Health · USRalph H. Johnson VA Medical Center · USSouthwestern Medical Center · USTrinity Medical Center · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Massachusetts Chan Medical School · USUniversity of Utah · USVanderbilt University Medical Center · USVirginia Commonwealth University · US
Funding
Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2002 to 2025
$7.7MA Multidisciplinary Analysis of Gelsolin Amyloid DiseaseR01AG018917 · SCRIPPS RESEARCH INSTITUTE · 2002 to 2005
$2.1MEXERCISE INTOLERANCE IN ELDERLY DIASTOLIC HEART FAILURER01AG018915 · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2001 to 2004
$1.4MPepper OAIC Coordinating CenterU24AG059624 · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2025 to 2025
$640kNHLBI NIH HHS HHSN268200900040CNHLBI NIH HHS HHSN268200900046CNHLBI NIH HHS HHSN268200900047CNHLBI NIH HHS HHSN268200900048CNHLBI NIH HHS HHSN268200900049CNHLBI NIH HHS R01 HL107257NIA NIH HHS P30 AG021332NIA NIH HHS R01 AG018915NIA NIH HHS R01 AG018917NIA NIH HHS R01 AG045551NIA NIH HHS U24 AG059624
Abstract
[Figure: see text].
Indexed as
AgedAntihypertensive AgentsAortaBlood PressureFemaleHumansHypertensionMagnetic Resonance Imaging, CineMaleMiddle AgedRegistriesVascular StiffnessAntihypertensive Agentsagingblood pressureelasticityheart failuremagnetic resonance imaging
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.