ArticleBehavioural brain research2021
Influence of anhedonic symptom severity on reward circuit connectivity in PTSD.
Article in Behavioural brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Abnormal resting-state functional connectivity in anhedonia: A systematic review and meta-analysis.Brain imaging and behavior · 2026Pooled it
- Effectiveness of Pleasure Perception Training Group Therapy on Adolescents With Depression and Analysis of Factors Associated With Non-Suicidal Self-Injurious Behaviors.International journal of methods in psychiatric research · 2026Trial
- Functional brain imaging in posttraumatic stress disorder: a review.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Aberrant neural event segmentation during a continuous social narrative in trauma-exposed older adolescents and young adults.Cognitive, affective & behavioral neuroscience · 2025Article
- Anhedonia as a Core Symptom of Depression and a Construct for Biological Research.Focus (American Psychiatric Publishing) · 2025Article
- Anhedonia is associated with higher functional connectivity between the nucleus accumbens and paraventricular nucleus of thalamus.Journal of affective disorders · 2024Article
- Evaluating state-based network dynamics in anhedonia.Neuroimage. Reports · 2024Article
- The nucleus accumbens in reward and aversion processing: insights and implications.Frontiers in behavioral neuroscience · 2024Review
- The main and interactive effects of distress tolerance and reward function on posttraumatic stress disorder symptoms among firefighters.Psychological trauma : theory, research, practice and policy · 2023Article
- Quantifying aberrant approach-avoidance conflict in psychopathology: A review of computational approaches.Neuroscience and biobehavioral reviews · 2023Review
- Anhedonia in Posttraumatic Stress Disorder: Prevalence, Phenotypes, and Neural Circuitry.Current topics in behavioral neurosciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Anhedonia, marked by deficits in reward processing, is a prominent symptom of several psychiatric conditions and has been shown to influence functional connectivity between reward-related regions. However, the unique influence of anhedonia severity on reward circuit connectivity in posttraumatic stress disorder (PTSD) remains unclear. To address this, we examined resting-state functional connectivity (rsFC) of the ventral striatum as a function of anhedonia for individuals with PTSD. Resting-state functional MRI scans and behavioral assessments were collected for 71 women diagnosed with PTSD. Seed-based voxelwise rsFC analyses for left and right nucleus accumbens (NAcc) seed regions of interest were performed. Voxelwise regression analyses were conducted to examine the relationship between anhedonia severity and rsFC of left and right NAcc. Results indicated that greater anhedonia severity was associated with reduced rsFC between the left NAcc and a cluster in the left caudate extending to the thalamus. This relationship between anhedonia and rsFC remained significant after controlling for PTSD symptom severity or depression severity. Our findings suggest that reward circuit dysfunction at rest is associated with anhedonia in PTSD. These results further contribute to our understanding of the neural correlates of anhedonia in psychiatric conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.