Evidence map›Paper›PMID 33776000›Full record

ArticleInternal medicine (Tokyo, Japan)2021

Successful Pregnancies in a Patient with Childhood-onset Steroid-dependent Nephrotic Syndrome during Rituximab Maintenance Therapy.

Mizuho Nara, Hajime Kaga, Masaya Saito, Fumito Abe, Ayano Saito, Chihiro Imaizumi, Atsushi Komatsuda, Hideki Wakui, Naoto Takahashi

Open access · diamondAbstract read
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mizuho NaraDepartment of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan.
Hajime KagaDepartment of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan.
Masaya SaitoDepartment of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan.
Fumito AbeDepartment of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan.
Ayano SaitoDepartment of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan.
Chihiro ImaizumiDepartment of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan.
Atsushi KomatsudaDepartment of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan.
Hideki WakuiDepartment of Life Science, Akita University Graduate School of Engineering Science, Japan.
Naoto TakahashiDepartment of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan.
Akita University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are an increasing number of reports on the safe use of rituximab (RTX), a chimeric anti-CD20 monoclonal antibody, in pregnant women with hematological malignancies or refractory autoimmune diseases. In 2014, the use of RTX for patients with complicated steroid-dependent nephrotic syndrome (SDNS) was approved in Japan. We herein report a woman with childhood-onset complicated SDNS due to focal and segmental glomerulosclerosis, who had two successful pregnancies while receiving RTX maintenance therapy. No adverse complications were observed during the pregnancies, and she delivered healthy newborns. This case suggested that RTX may be used safely in pregnant women complicated with SDNS.

Indexed as

Glomerulosclerosis, Focal SegmentalNephrotic SyndromeChildFemaleHumansImmunologic FactorsImmunosuppressive AgentsInfant, NewbornJapanPregnancyRituximabSteroidsTreatment OutcomeImmunologic FactorsImmunosuppressive AgentsRituximabSteroidschildhood-onset steroid-dependent nephrotic syndromefocal segmental glomerulosclerosispregnancyrituximabsafety use

Identifiers

PMID33776000
PMCPMC8502647
OpenAlexW3149319700

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.