ArticleJournal of fluid mechanics2021
The effect of viscoelasticity in an airway closure model.
Article in Journal of fluid mechanics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Human lungs fluid mechanics: an overview of current modelling techniques.The European physical journal. E, Soft matter · 2026Review
- Thixo-viscoelastoplastic rheological characterisation of human mucus using a multimode BMP constitutive equation approach.Scientific reports · 2025Article
- Comparison of airway opening pressure measurements: low-constant-flow vs. constant low-slope pressure ramp methods.BMC anesthesiology · 2025Observational
- Effects of Kinematic Hardening of Mucus Polymers in an Airway Closure Model.Journal of non-Newtonian fluid mechanics · 2024Article
- Liquid plug propagation in computer-controlled microfluidic airway-on-a-chip with semi-circular microchannels.Lab on a chip · 2024Article
- Surfactant amplifies yield-stress effects in the capillary instability of a film coating a tube.Journal of fluid mechanics · 2023Article
- Physiology and pathophysiology of human airway mucus.Physiological reviews · 2022Review
- Impact of partial slip and lateral walls on peristaltic transport of a couple stress fluid in a rectangular duct.Science progressArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The closure of a human lung airway is modeled as a pipe coated internally with a liquid that takes into account the viscoelastic properties of mucus. For a thick enough coating, the Plateau-Rayleigh instability blocks the airway by the creation of a liquid plug, and the pre-closure phase is dominated by the Newtonian behavior of the liquid. Our previous study with a Newtonian-liquid model demonstrated that the bifrontal plug growth consequent to airway closure induces a high level of stress and stress gradients on the airway wall, which is large enough to damage the epithelial cells, causing sub-lethal or lethal responses. In this study, we explore the effect of the viscoelastic properties of mucus by means of the Oldroyd-B and FENE-CR model. Viscoelasticity is shown to be very relevant in the post-coalescence process, introducing a second peak of the wall shear stresses. This second peak is related to an elastic instability due to the presence of the polymeric extra stresses. For high-enough Weissenberg and Laplace numbers, this second shear stress peak is as severe as the first one. Consequently, a second lethal or sub-lethal response of the epithelial cells is induced.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.