Evidence map›Paper›PMID 33776792›Full record

ArticleFrontiers in physiology2021

Disturbed Blood Flow Acutely Increases Endothelial Microparticles and Decreases Flow Mediated Dilation in Patients With Heart Failure With Reduced Ejection Fraction.

Thiago O C Silva, Allan R K Sales, Gustavo S M Araujo, Guilherme W P Fonseca, Pedro G S Braga, Diego Faria, Helena N M Rocha, Natalia G Rocha, Marta F Lima, Charles Mady and 2 more

Open access · goldAbstract read
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In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Thiago O C SilvaHeart Institute, University of São Paulo Medical School, São Paulo, Brazil.
Allan R K SalesHeart Institute, University of São Paulo Medical School, São Paulo, Brazil.
Gustavo S M AraujoHeart Institute, University of São Paulo Medical School, São Paulo, Brazil.
Guilherme W P FonsecaHeart Institute, University of São Paulo Medical School, São Paulo, Brazil.
Pedro G S BragaHeart Institute, University of São Paulo Medical School, São Paulo, Brazil.
Diego FariaD'OR Institute for Research and Education, São Paulo, Brazil.
Helena N M RochaDepartment of Physiology and Pharmacology, Fluminense Federal University, Niteroi, Brazil.
Natalia G RochaDepartment of Physiology and Pharmacology, Fluminense Federal University, Niteroi, Brazil.
Marta F LimaHeart Institute, University of São Paulo Medical School, São Paulo, Brazil.
Charles MadyHeart Institute, University of São Paulo Medical School, São Paulo, Brazil.
Carlos E NegrãoHeart Institute, University of São Paulo Medical School, São Paulo, Brazil.
Maria Janieire N N AlvesHeart Institute, University of São Paulo Medical School, São Paulo, Brazil.
Universidade de São Paulo · BRD’Or Institute for Research and Education · BRUniversidade Federal Fluminense · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDisturbed blood flow, characterized by high retrograde and oscillatory shear rate (SR), is associated with a proatherogenic phenotype. The impact of disturbed blood flow in patients with heart failure with reduced ejection fraction (HFrEF) remains unknown. We tested the hypothesis that acute elevation to retrograde and oscillatory SR provoked by local circulatory occlusion would increase endothelial microparticles (EMPs) and decrease brachial artery flow-mediated dilation (FMD) in patients with HFrEF.

methodsEighteen patients with HFrEF aged 55 ± 2 years, with left ventricular ejection fraction (LVEF) 26 ± 1%, and 14 control subjects aged 49 ± 2 years with LVEF 65 ± 1 randomly underwent experimental and control sessions. Brachial artery FMD (Doppler) was evaluated before and after 30 min of disturbed forearm blood flow provoked by pneumatic cuff (Hokanson) inflation to 75 mm Hg. Venous blood samples were collected at rest, after 15 and 30 min of disturbed blood flow to assess circulating EMP levels (CD42b-/CD31+; flow cytometry).

resultsAt rest, FMD was lower in patients with HFrEF compared with control subjects (

conclusionCollectively, our findings suggest that disturbed blood flow acutely decreases FMD and increases EMP levels in patients with HFrEF, which may indicate that this set of patients are vulnerable to blood flow disturbances.

Indexed as

disturbed blood flowendothelial functionendothelial microparticlesheart failurevascular

Identifiers

PMID33776792
PMCPMC7991910
OpenAlexW3135509818

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.