Evidence map›Paper›PMID 33778320›Full record

ArticleJBMR plus2021

Low-Dose Tamoxifen Induces Significant Bone Formation in Mice.

Zhihui Xie, Cody McGrath, Jeyantt Sankaran, Maya Styner, Sarah Little-Letsinger, Amel Dudakovic, Andre J van Wijnen, Janet Rubin, Buer Sen

Open access · goldAbstract read
In one paragraph

Article in JBMR plus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Rational evolution for altering the ligand preference of estrogen receptor alpha.Protein science : a publication of the Protein Society · 2024
    Article
  3. Review
  4. Article
  5. Review
  6. Bone mineralisation and glucose metabolism.Current opinion in endocrine and metabolic research · 2023
    Review
  7. Review
  8. Skeletal Effects of Inducible ERα Deletion in Osteocytes in Adult Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Article
  9. Ciliary IFT88 Protects Coordinated Adolescent Growth Plate Ossification From Disruptive Physiological Mechanical Forces.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Zhihui XieDepartment of Medicine University of North Carolina Chapel Hill NC USA.
Cody McGrathDepartment of Medicine University of North Carolina Chapel Hill NC USA.
Jeyantt SankaranDepartment of Medicine University of North Carolina Chapel Hill NC USA.
Maya StynerDepartment of Medicine University of North Carolina Chapel Hill NC USA.ORCID https://orcid.org/0000-0001-9790-8645
Sarah Little-LetsingerDepartment of Medicine University of North Carolina Chapel Hill NC USA.
Amel DudakovicDepartment of Orthopedic Surgery and Biochemistry and Molecular Biology Mayo Clinic Rochester MN USA.ORCID https://orcid.org/0000-0002-8850-3977
Andre J van WijnenDepartment of Orthopedic Surgery and Biochemistry and Molecular Biology Mayo Clinic Rochester MN USA.
Janet RubinDepartment of Medicine University of North Carolina Chapel Hill NC USA.ORCID https://orcid.org/0000-0003-3534-8667
Buer SenDepartment of Medicine University of North Carolina Chapel Hill NC USA.ORCID https://orcid.org/0000-0002-0487-7817
University of North Carolina at Chapel Hill · USMayo Clinic · US

Funding

ELECTRIC FIELD ATTENUATION OF OSTEOCLAST FORMATIONR01AR042360 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUBIN, JANET E · 1993 to 2013
$2.8M
Role of force regulated nuclear structure in expression of osteogenesisR01AR075803 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUBIN, JANET E · 2020 to 2024
$2.4M
Marrow Adipose Compartment Physiology in Caloric Restriction and AgingR01AR073264 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STYNER, MAYA SHALEV · 2019 to 2023
$1.7M
NIAMS NIH HHS R01 AR042360NIAMS NIH HHS R01 AR073264NIAMS NIH HHS R01 AR075803
6 · The paper itself

Abstract

Use of the selective estrogen receptor modulator Tamoxifen (TAM) is a mainstay to induce conditional expression of Cre recombinase in transgenic laboratory mice. To excise β-catenin

Indexed as

CONDITIONAL KNOCKOUTOSTEOCLASTμCT

Identifiers

PMID33778320
PMCPMC7990151
OpenAlexW3112261462

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.