ReviewRadiology. Cardiothoracic imaging2021
Assessing Cardiovascular Risk by Using the Fat Attenuation Index in Coronary CT Angiography.
Review in Radiology. Cardiothoracic imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06557811 (Effect of Oral Semaglutide on Epicardial and Pericoronary Adipose Tissues in Type 2 Diabetes After Myocardial Infarction), which is not on this map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Oral Semaglutide on Epicardial and Pericoronary Adipose Tissues in Type 2 Diabetes After Myocardial Infarction: a Randomized and Double-blind Clinical Trial
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Correlation Between Fat Attenuation Index and Major Adverse Cardiovascular Events: A Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2026Pooled it
- Beyond Angiography: Redefining The Gold Standard for Coronary Atherosclerosis.Current cardiology reports · 2026Review
- Review
- Effect of imaging parameters and clinical characteristics on pericoronary adipose tissue attenuation in patients without coronary plaque.Quantitative imaging in medicine and surgery · 2026Article
- Targeting perivascular adipose tissue in vascular aging: innovative translational strategies for disease prevention and monitoring.Apoptosis : an international journal on programmed cell death · 2026Review
- Quantitative assessment of coronary peri-vascular fat attenuation index using dual-layer spectral CT for differentiating high-risk plaques in coronary artery disease.BMC medical imaging · 2026Article
- Heart matters: How glucose- and lipid-modulating drugs remodel epicardial adipose tissue accumulation, inflammatory patterns and browning.Diabetes, obesity & metabolism · 2026Review
- Inflammation and Resolution in Obesity-Related Cardiovascular Disease.International journal of molecular sciences · 2026Review
- Prognostic Value of Composite Biomarkers Integrating Insulin Resistance and Coronary Inflammation for Major Adverse Cardiovascular Events in Post-PCI Patients with Coronary Artery Disease Across Glycemic Status: A Prospective Cohort Study.Journal of inflammation research · 2026Article
- Lipoprotein(a) is associated with coronary inflammation in people with HIV and undetectable HIV RNA.European heart journal. Imaging methods and practice · 2026Article
- Inflammatory Mechanisms in Acute Coronary Syndromes: From Pathophysiology to Therapeutic Targets.Cells · 2025Review
- Machine learning-based radiomic features of perivascular adipose tissue in coronary computed tomography angiography predicting inflammation status around atherosclerotic plaque: a retrospective cohort study.Annals of medicine · 2025Article
- Additive value of perivascular fat density to CT angiography characteristics of carotid plaques in predicting symptomatic carotid plaques.European radiology · 2025Article
- Position Statement on Cardiometabolic Health Across the Woman's Life Course - 2025.Arquivos brasileiros de cardiologia · 2025Article
- Cardiac computed tomography-derived fat attenuation index in coronary vasculitis: inflammation development over a year.European heart journal. Case reports · 2025Article
- Novel Strategies to Conquer Residual Adiposity Risk in Cardiovascular Disease.Current atherosclerosis reports · 2025Review
- Assessment of the Association Between Coronary Artery Calcification, Plaque Vulnerability, and Perivascular Inflammation via Coronary CT Angiography.Life (Basel, Switzerland) · 2025Article
- Quantification of water and lipid composition of perivascular adipose tissue using coronary CT angiography: a simulation study.The international journal of cardiovascular imaging · 2025Article
- The pericoronary adipose tissue attenuation in CT strongly depends on kernels and iterative reconstructions.European radiology · 2025Article
- Mechanotransduction in the Perivascular Adipose Tissue.Arteriosclerosis, thrombosis, and vascular biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Coronary CT angiography (CCTA) has evolved into a first-line diagnostic test for the investigation of chest pain. Despite advances toward standardizing the reporting of CCTA through the Coronary Artery Disease Reporting and Data System (or CAD-RADS) tool, the prognostic value of CCTA in the earliest stages of atherosclerosis remains limited. Translational work on the bidirectional interplay between the coronary arteries and the perivascular adipose tissue (PVAT) has highlighted PVAT as an in vivo molecular sensor of coronary inflammation. Coronary inflammation is dynamically associated with phenotypic changes in its adjacent PVAT, which can now be detected as perivascular attenuation gradients at CCTA. These gradients are captured and quantified through the fat attenuation index (FAI), a CCTA-based biomarker of coronary inflammation. FAI carries significant prognostic value in both primary and secondary prevention (patients with and without established coronary artery disease) and offers a significant improvement in cardiac risk discrimination beyond traditional risk factors, such as coronary calcium, high-risk plaque features, or the extent of coronary atherosclerosis. Thanks to its dynamic nature, FAI may be used as a marker of disease activity, with observational studies further suggesting that it tracks the response to anti-inflammatory interventions. Finally, radiotranscriptomic studies have revealed complementary radiomic patterns of PVAT, which detect more permanent adverse fibrotic and vascular PVAT remodeling, further expanding the value of PVAT phenotyping as an important readout in modern CCTA analysis. © RSNA, 2021.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.