ArticleThe Journal of international medical research2021
Relationship between serum bilirubin concentration and sarcopenia in patients with type 2 diabetes: a cross-sectional study.
Article in The Journal of international medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.
- Systematic review and meta-analysis of biomarkers of sarcopenia and sarcopenic obesity.Medicine · 2026Pooled it
- Pathophysiological Mechanisms Underlying Sarcopenia and Sarcopenic Obesity: A Systematic Review and Meta-Analysis of Biomarker Evidence.International journal of molecular sciences · 2025Pooled it
- Serum bilirubin concentrations in peritoneal dialysis patients are correlated with the initial onset of peritonitis.BMC nephrology · 2025Article
- Construction and validation of a nomogram for screening for sarcopenia in patients with osteoporotic vertebral compression fracture.Scientific reports · 2025Article
- Association between total bilirubin and sarcopenia in people with type 2 diabetes: The KAMOGAWA-A study.Endocrine journal · 2025Article
- Assessing Association Between Circulating Bilirubin Levels and the Risk of Frailty: An Observational and Mendelian Randomization Study.Journal of cachexia, sarcopenia and muscle · 2025Observational
- Relationship between uric acid to high-density lipoprotein cholesterol ratio and sarcopenia in NHANES: exploring the mediating role of bilirubin and association with all-cause mortality.Frontiers in nutrition · 2025Article
- Exposure to volatile organic compounds increases the risk of sarcopenia: Insights into association and mechanism.PloS one · 2025Article
- Bile Acids and Bilirubin Role in Oxidative Stress and Inflammation in Cardiovascular Diseases.Diseases (Basel, Switzerland) · 2024Review
- Associations of oxidative stress markers with the prevalence of sarcopenia in the United States general population.Clinics (Sao Paulo, Brazil) · 2024Article
- The physiology of bilirubin: health and disease equilibrium.Trends in molecular medicine · 2023Review
- Deep Learning-Based Muscle Segmentation and Quantification of Full-Leg Plain Radiograph for Sarcopenia Screening in Patients Undergoing Total Knee Arthroplasty.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe prevalence of sarcopenia is high in patients with type 2 diabetes mellitus (T2DM). Oxidative stress and inflammation play important roles in the pathogenesis of sarcopenia in diabetes. Bilirubin has been shown to possess anti-oxidative activity. We aimed to explore the relationship between bilirubin and sarcopenia in patients with T2DM.
methodsA total of 251 patients (124 men and 127 postmenopausal women) with T2DM, aged ≥50 years, participated in a cross-sectional study. The serum concentrations of bilirubin (TBIL), direct bilirubin (DBIL) and indirect bilirubin (IBIL) were measured. Muscle mass was measured using dual-energy X-ray absorptiometry.
resultsTBIL and IBIL were positively associated with appendicular skeletal muscle mass index (SMI) in men, but not in women. After adjustment for multiple factors in multiple linear regression analysis, TBIL and IBIL were also significantly associated with SMI in men. In multiple logistic regression analysis, participants in the highest quartile of IBIL demonstrated a lower odds ratio for sarcopenia in men.
conclusionsBoth TBIL and IBIL are positively associated with muscle mass in men with T2DM. Furthermore, IBIL may protect against sarcopenia in men with T2DM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.