Evidence map›Paper›PMID 33781275›Full record

Trial reportJournal of translational medicine2021

The effect of omega-3 fatty acid supplementation on clinical and biochemical parameters of critically ill patients with COVID-19: a randomized clinical trial.

Saeid Doaei, Somayeh Gholami, Samira Rastgoo, Maryam Gholamalizadeh, Fatemeh Bourbour, Seyedeh Elaheh Bagheri, Forough Samipoor, Mohammad Esmail Akbari, Mahdi Shadnoush, Fereshteh Ghorat and 6 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Saeid DoaeiResearch Center of Health and Environment, School of Health, Guilan University of Medical Sciences, Rasht, Iran.
Somayeh GholamiRazi Hospital, Guilan University of Medical Sciences, Rasht, Iran.
Samira RastgooNational Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Maryam GholamalizadehStudent Research Committee, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fatemeh BourbourNational Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Seyedeh Elaheh BagheriSchool of Paramedicine, Guilan University of Medical Sciences, Langroud, Iran.
Forough SamipoorRazi Hospital, Guilan University of Medical Sciences, Rasht, Iran.
Mohammad Esmail AkbariCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mahdi ShadnoushDepartment of Clinical Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fereshteh GhoratTraditional and Complementary Medicine Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Seyed Alireza Mosavi JarrahiCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Narjes Ashouri MirsadeghiNational Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Azadeh HajipourSchool of Health, Qazvin University of Medical Sciences, Qazvin, Iran.
Parvin JoolaDepartment of Non-Communicable Disease, Deputy of Health Services, Dezful University of Medical Sciences, Dezful, Iran.
Alireza MoslemIranian Research Center on Healthy Aging, Sabzevar University of Medical Sciences, Sabzevar, Iran. Crc.sbmu2018@gmail.com.
Mark O GoodarziDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOmega-3 polyunsaturated fatty acids (n3-PUFAs) may exert beneficial effects on the immune system of patients with viral infections. This paper aimed to examine the effect of n3-PUFA supplementation on inflammatory and biochemical markers in critically ill patients with COVID-19.

methodsA double-blind, randomized clinical trial study was conducted on 128 critically ill patients infected with COVID-19 who were randomly assigned to the intervention (fortified formula with n3-PUFA) (n = 42) and control (n = 86) groups. Data on 1 month survival rate, blood glucose, sodium (Na), potassium (K), blood urea nitrogen (BUN), creatinine (Cr), albumin, hematocrit (HCT), calcium (Ca), phosphorus (P), mean arterial pressure (MAP), O

resultsThe intervention group had significantly higher 1-month survival rate and higher levels of arterial pH, HCO

conclusionOmega-3 supplementation improved the levels of several parameters of respiratory and renal function in critically ill patients with COVID-19. Further clinical studies are warranted. Trial registry Name of the registry: This study was registered in the Iranian Registry of Clinical Trials (IRCT); Trial registration number: IRCT20151226025699N3; Date of registration: 2020.5.20; URL of trial registry record: https://en.irct.ir/trial/48213.

Indexed as

AdultAgedAged, 80 and overBiomarkersBlood Gas AnalysisBlood GlucoseCOVID-19Critical IllnessDietary SupplementsDouble-Blind MethodFatty Acids, Omega-3FemaleHematocritHumansInflammation MediatorsIranBiomarkersBlood GlucoseFatty Acids, Omega-3Inflammation MediatorsCoronavirusKidney functionOmega-3 fatty acidsRespiratory function

Identifiers

PMID33781275
PMCPMC8006115

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.