Evidence map›Paper›PMID 33782196›Full record

ArticleStroke and vascular neurology2021

Identifying sex-specific differences in the carotid revascularisation literature: findings from a scoping review.

Vignan Yogendrakumar, Michel Shamy, Brian Dewar, Dean A Fergusson, Dar Dowlatshahi, Candyce Hamel, Sophia Gocan, Mark Fedyk, Jean-Louis Mas, Peter Rothwell and 3 more

Open access · goldAbstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke and vascular neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Vignan YogendrakumarDepartment of Medicine, Division of Neurology and Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.ORCID 0000-0001-8814-6853
Michel ShamyDepartment of Medicine, Division of Neurology and Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada mshamy@toh.ca.
Brian DewarDepartment of Medicine, Division of Neurology and Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
Dean A FergussonEpidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Dar DowlatshahiDepartment of Medicine, Division of Neurology and Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
Candyce HamelEpidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Sophia GocanStroke Prevention Clinic, Ottawa Hospital, Ottawa, Ontario, Canada.
Mark FedykBioethics Program, UC Davis Department of Medicine, Sacramento, California, USA.ORCID 0000-0002-0815-662X
Jean-Louis MasUniversite Paris Descartes Faculte de Medecine Site Cochin, Paris, Île-de-France, France.
Peter RothwellService de Neurologie, Hôpital Sainte-Anne, Paris, France.
Virginia HowardThe University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.
Olena BereznyakovaSchool of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.
WoW-CAD Investigators
University of Ottawa · CAOttawa Hospital · CAUniversity of Alabama at Birmingham · USCentre Hospitalier Sainte-Anne · FRDélégation Paris 5 · FRUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveNo systematic review of the literature has dedicated itself to looking at the management of symptomatic carotid stenosis in female patients. In this scoping review, we aimed to identify all randomised controlled trials (RCTs) that reported sex-specific outcomes for patients who underwent carotid revascularisation, and determine whether sufficient information is reported within these studies to assess short-term and long-term outcomes in female patients. DESIGN, SETTING AND

participantsWe systematically searched Medline, Embase, Pubmed and Cochrane libraries for RCTs published between 1991 and 2020 that included female patients and compared either endarterectomy with stenting, or any revascularisation (endarterectomy or stenting) with medical therapy in patients with symptomatic high-grade (>50%) carotid stenosis.

resultsFrom 1537 references examined, 27 eligible studies were identified. Sex-specific outcomes were reported in 13 studies. Baseline patient characteristics of enrolled female patients were reported in 2 of those 13 studies. Common outcomes reported included stroke and death, however, there was significant heterogeneity in the reporting of both periprocedural and long-term outcomes. Sex-specific differences relating to the degree of stenosis and time from index event to treatment are largely limited to studies comparing endarterectomy to medical therapy. Adverse events were not reported by sex.

conclusionsOnly half of the previously published RCTs and systematic reviews report sex-specific outcomes. Detailed analyses on the results of carotid artery intervention for female patients with symptomatic stenosis are limited.

Indexed as

Carotid StenosisEndarterectomy, CarotidCarotid ArteriesFemaleHumansMaleStentsTreatment Outcomeatherosclerosisinterventionstenosisstent

Identifiers

PMID33782196
PMCPMC8485244
OpenAlexW3151430763

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.