Evidence map›Paper›PMID 33782383›Full record

Trial reportTranslational psychiatry2021

A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder.

Philip E Mosley, François Windels, John Morris, Terry Coyne, Rodney Marsh, Andrea Giorni, Adith Mohan, Perminder Sachdev, Emily O'Leary, Mark Boschen and 2 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 5 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 5 syntheses or guidelines pooled it, 103 citations in OpenAlex.

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  20. Neuropsychiatric symptoms in Alzheimer's disease: Bridging mechanisms, management, and emerging innovations.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Philip E MosleySystems Neuroscience Group, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. philip.mosley@qimrberghofer.edu.au.ORCID 0000-0003-1721-3419
François WindelsQueensland Brain Institute, University of Queensland, St Lucia, QLD, Australia.ORCID 0000-0001-5341-2197
John MorrisQueensland Brain Institute, University of Queensland, St Lucia, QLD, Australia.
Terry CoyneQueensland Brain Institute, University of Queensland, St Lucia, QLD, Australia.
Rodney MarshNeurosciences Queensland, St Andrew's War Memorial Hospital, Spring Hill, QLD, Australia.
Andrea GiorniQueensland Brain Institute, University of Queensland, St Lucia, QLD, Australia.
Adith MohanCentre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
Perminder SachdevCentre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.ORCID 0000-0002-9595-3220
Emily O'LearyThe OCD Clinic, Bulimba, QLD, Australia.
Mark BoschenSchool of Applied Psychology, Griffith University, Gold Coast, QLD, Australia.
Pankaj Sah *Queensland Brain Institute, University of Queensland, St Lucia, QLD, Australia.ORCID 0000-0001-5063-1589
Peter A Silburn *Neurosciences Queensland, St Andrew's War Memorial Hospital, Spring Hill, QLD, Australia.
The University of Queensland · AUUNSW Sydney · AUGriffith University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep brain stimulation (DBS) is a promising treatment for severe, treatment-resistant obsessive-compulsive disorder (OCD). Here, nine participants (four females, mean age 47.9 ± 10.7 years) were implanted with DBS electrodes bilaterally in the bed nucleus of the stria terminalis (BNST). Following a one-month postoperative recovery phase, participants entered a three-month randomised, double-blind, sham-controlled phase before a twelve-month period of open-label stimulation incorporating a course of cognitive behavioural therapy (CBT). The primary outcome measure was OCD symptoms as rated with the Yale-Brown Obsessive-Compulsive Scale (YBOCS). In the blinded phase, there was a significant benefit of active stimulation over sham (p = 0.025, mean difference 4.9 points). After the open phase, the mean reduction in YBOCS was 16.6 ± 1.9 points (χ

Indexed as

Deep Brain StimulationObsessive-Compulsive DisorderSeptal NucleiAdultDouble-Blind MethodFemaleHumansMiddle AgedThalamusTreatment Outcome

Identifiers

PMID33782383
PMCPMC8007749
OpenAlexW3142541078

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.