ReviewDrug and alcohol review2021
The role of alcohol use in the aetiology and progression of liver disease: A narrative review and a quantification.
Review in Drug and alcohol review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- A review of the relationship between dimensions of alcohol consumption and the burden of disease: 2026 update including Mendelian randomisation studies.Addiction (Abingdon, England) · 2026Pooled it
- How does alcohol use impact morbidity and mortality of liver cirrhosis? A systematic review and dose-response meta-analysis.Hepatology international · 2024Pooled it
- Designing Effective Alcohol Warnings: Consumer Reactions to Icons and Health Topics.American journal of preventive medicine · 2023Trial
- GLP-1 Receptor Agonist and GIP/GLP-1 Receptor Dual Agonist Therapeutics at the Intersection of Alcohol Use Disorder, Obesity, and Cardiometabolic Dysfunction.Biological psychiatry global open science · 2026Review
- Steatotic liver disease in Latin America: current views and perspectives.Nature reviews. Gastroenterology & hepatology · 2026Review
- Global epidemiology of metabolic and alcohol-associated liver disease: risk factors, natural history and clinical implications.Nature reviews. Gastroenterology & hepatology · 2026Review
- Alcohol Use and Attributable Burden of Disease in the World Health Organization Western Pacific Region.Drug and alcohol review · 2026Article
- Preparation and Identification of Corn-Derived Bioactive Peptides with Triple Efficacy of ADH-Activating, XOD-Inhibiting and Antioxidant Activity.Foods (Basel, Switzerland) · 2026Article
- Prevalence and factors associated with risky alcohol consumption in nursing students at the university of Castilla-La Mancha.BMC nursing · 2026Article
- LC-Pred: A Transformer-Based Interactive Interface for Liver Cirrhosis Prediction.International journal of hepatology · 2026Article
- Clinical trial design, biomarkers and end points in metabolic and alcohol-related liver disease.Nature reviews. Gastroenterology & hepatology · 2025Review
- A Practical Guide to Conducting Dose-Response Meta-Analyses in Epidemiology.Methodology : European journal of research methods for the behavioral & social sciences · 2025Article
- How does taxation affect liver cirrhosis across age groups? An analysis of alcohol control policies on liver cirrhosis outcomes in Lithuania between 2001 and 2022.Alcohol and alcoholism (Oxford, Oxfordshire) · 2025Article
- MetALD: New Perspectives on an Old Overlooked Disease.Liver international : official journal of the International Association for the Study of the Liver · 2025Review
- Metabolic dysfunction and alcohol-related liver disease (MetALD): Position statement by an expert panel on alcohol-related liver disease.Journal of hepatology · 2025Review
- A Brief Cognitive Behavioral Therapy-Based Digital Intervention for Reducing Hazardous Alcohol Use in South Korea: Development and Prospective Pilot Study.JMIR formative research · 2025Article
- Targeting socioeconomic inequity to reduce liver disease related to alcohol use.The lancet. Gastroenterology & hepatology · 2025Article
- Primary liver cancer burden and its association with health development in the Western Pacific, 1990-2021.Frontiers in oncology · 2025Article
- Propensity Score Matching Analysis for Alcohol-Related Liver Disease.Health science reports · 2025Article
- Liver stiffness and associated risk factors among people with a history of injecting drugs: a prospective cohort study.Substance abuse treatment, prevention, and policy · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 6 countries.
Funding
Abstract
issuesAlcohol use has been shown to impact on various forms of liver disease, not restricted to alcoholic liver disease. APPROACH: We developed a conceptual framework based on a narrative review of the literature to identify causal associations between alcohol use and various forms of liver disease including the complex interactions of alcohol with other major risk factors. Based on this framework, we estimate the identified relations for 2017 for the USA. KEY
findingsThe following pathways were identified and modelled for the USA for the year 2017. Alcohol use caused 35 200 (95% uncertainty interval 32 800-37 800) incident cases of alcoholic liver cirrhosis. There were 1700 (uncertainty interval 1100-2500) acute hepatitis B and C virus (HBV and HCV) infections attributable to heavy-drinking occasions, and 14 000 (uncertainty interval 5900-19 500) chronic HBV and 1700 (uncertainty interval 700-2400) chronic HCV infections due to heavy alcohol use interfering with spontaneous clearance. Alcohol use and its interactions with other risk factors (HBV, HCV, obesity) led to 54 500 (uncertainty interval 50 900-58 400) new cases of liver cirrhosis. In addition, alcohol use caused 6600 (uncertainty interval 4200-9300) liver cancer deaths and 40 700 (uncertainty interval 36 600-44 600) liver cirrhosis deaths. IMPLICATIONS: Alcohol use causes a substantial number of incident cases and deaths from chronic liver disease, often in interaction with other risk factors.
conclusionThis additional disease burden is not reflected in the current alcoholic liver disease categories. Clinical work and prevention policies need to take this into consideration.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.