SynthesisAging clinical and experimental research2021
Does vitamin D improve symptomatic and structural outcomes in knee osteoarthritis? A systematic review and meta-analysis.
Synthesis in Aging clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Shining light on knee osteoarthritis: an overview of vitamin D supplementation studies.Frontiers in medicine · 2024Pooled it
- Relationship between 25-hydroxy vitamin D and knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2023Pooled it
- A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms.Nutrients · 2022Pooled it
- A clinical model to predict the progression of knee osteoarthritis: data from Dryad.Journal of orthopaedic surgery and research · 2023Trial
- Food Supplements in Osteoarthritis: A Practical Framework for Discussing Evidence with Patients.Nutrients · 2026Review
- Relation of Serum Vitamin-D Level with Serum Interleukin-6 and Interleukin-10 in Patients with Primary Osteoarthritis of Knee.Journal of orthopaedic case reports · 2025Article
- Vitamin D and bone health: from physiological function to disease association.Nutrition & metabolism · 2025Review
- Diet in Knee Osteoarthritis-Myths and Facts.Nutrients · 2025Review
- Cathepsin K Inhibitors as Potential Drugs for the Treatment of Osteoarthritis.International journal of molecular sciences · 2025Review
- Associations between nutrient intake and osteoarthritis based on NHANES 1999 to 2018 cross sectional study.Scientific reports · 2025Article
- Nonsurgical Knee Osteoarthritis Treatments for Reducing Inflammation as Measured on MRI Scans: A Systematic Review of Randomized Controlled Trials.Orthopaedic journal of sports medicine · 2024Review
- Current Evidence on and Clinical Implications of Vitamin D Levels in Pain and Functional Management of Knee Osteoarthritis: A Systematic Review.Clinics and practice · 2024Review
- Association between Dietary total antioxidant capacity and knee osteoarthritis: a case-control study in the Iranian Population.BMC musculoskeletal disorders · 2024Article
- Article
- Effect of vitamin D supplementation on circulating level of autophagosome protein LC3A, inflammation, and physical performance in knee osteoarthritis.Clinical and translational science · 2023Article
- Article
- Subchondral bone in knee osteoarthritis: bystander or treatment target?Skeletal radiology · 2023Review
- Review
- The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis.Immunologic research · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo provide evidence on the effects of vitamin D supplementation on knee osteoarthritis (KOA) and new targets for clinical prevention and treatment of KOA.
methodThe PubMed, Embase, Web of science, Wanfang, CNKI and SinoMed databases were retrieved to investigate the effects of vitamin D supplementation on patients with KOA. The search time was from databases establishment to 15 November 2020. RevMan5.3 software was used for meta-analysis. The results were expressed as standardized mean difference (SMD) with 95% confidence interval (CI) or weighted mean difference (WMD) with 95% confidence interval (CI).
resultsA total of 1599 patients with osteoarthritis of the knee were included in the study, which involved six articles. The results of the meta-analysis showed that vitamin D supplementation is statistically significant for WOMAC score (SMD = - 0.67, 95% CI - 1.23 to - 0.12) in patients with KOA, including WOMAC pain score (SMD = - 0.32, 95% CI - 0.63 to - 0.02), function score (SMD = - 0.34, 95% CI - 0.60 to - 0.08) and stiffness score (SMD = - 0.13, 95% CI - 0.26 to - 0.01). In subgroup analysis, vitamin D supplementation less than 2000 IU was statistically significant for the reduction of stiffness score (SMD = - 0.22, 95% CI - 0.40 to - 0.04). Vitamin D supplements can reduce synovial fluid volume progression in patients with KOA (SMD = - 0.20, 95% CI - 0.39 to - 0.02). There was no statistical significance in improving tibia cartilage volume (SMD = 0.12, 95% CI - 0.05 to 0.29), joint space width (SMD = - 0.10, 95% CI - 0.26 to 0.05) and bone marrow lesions (SMD = 0.03, 95% CI - 0.26 to 0.31).
conclusionVitamin D supplements can improve WOMAC pain and function in patients with KOA. But there is a lack of strong evidence that vitamin D supplementation can prevent structural progression in patients with KOA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.