Evidence map›Paper›PMID 33788138›Full record

ArticleJournal of neurovirology2021

Assessment, prevalence, and correlates of frailty among middle-aged adults with HIV in rural Uganda.

Alyssa Vecchio, Gertrude Nakigozi, Noeline Nakasujja, Alice Kisakye, James Batte, Richard Mayanja, Aggrey Anok, Kevin Robertson, Maria J Wawer, Ned Sacktor and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of neurovirology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Alyssa VecchioUniversity of North Carolina-Chapel Hill, Chapel Hill, NC, USA. alyssacv@med.unc.edu.
Gertrude NakigoziMakerere University, Kampala, Uganda.
Noeline NakasujjaRakai Health Sciences Program, Kalisizo, Uganda.
Alice KisakyeRakai Health Sciences Program, Kalisizo, Uganda.
James BatteRakai Health Sciences Program, Kalisizo, Uganda.
Richard MayanjaRakai Health Sciences Program, Kalisizo, Uganda.
Aggrey AnokRakai Health Sciences Program, Kalisizo, Uganda.
Kevin RobertsonUniversity of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
Maria J WawerJohns Hopkins Bloomberg School of Public Health, Baltimore, USA.
Ned SacktorJohns Hopkins University School of Medicine, Baltimore, USA.
Leah H RubinJohns Hopkins Bloomberg School of Public Health, Baltimore, USA.
Deanna SaylorJohns Hopkins University School of Medicine, Baltimore, USA.
Rakai Health Sciences Program · UGJohns Hopkins Medicine · USJohns Hopkins University · USUniversity of North Carolina at Chapel Hill · USMakerere University · UG

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ALLISON L AGWU · 2012 to 2026
$67.0M
Therapeutic CoreP30MH075673 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Leah Helane Rubin · 2006 to 2026
$33.2M
Research Education Program for Residents and Fellows in Neurology - PorrasR25NS065729 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HILLIS, ARGYE E. · 2009 to 2024
$3.3M
Neurologic Sequelae of HIV Subtype A and D Infection and ART Rakai UgandaR01MH099733 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SACKTOR, NED C, WAWER, MARIA J · 2013 to 2017
$3.0M
Translational Research in Neuro-AIDS and Mental HealthR25MH080661 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MCARTHUR, JUSTIN CHARLES. · 2007 to 2019
$2.9M
NIAID NIH HHS P30 AI094189NIMH NIH HHS P30 MH075673NIMH NIH HHS R01 MH099733NIMH NIH HHS R25 MH080661NINDS NIH HHS L30 NS088658NINDS NIH HHS R25 NS065729
6 · The paper itself

Abstract

We investigated the prevalence and risk factors for frailty among people with HIV (PWH) in rural Uganda (n = 55, 47% male, mean age 44 years). Frailty was defined according to the Fried criteria with self-reported physical activity level replacing the Minnesota Leisure Time Activity Questionnaire. Alternate classifications for physical activity utilized were the sub-Saharan Africa Activity Questionnaire and the International Physical Activity Questionnaire. Eleven participants (19%) were frail. Frail participants were older (p < 0.001), less likely to be on antiretroviral therapy (p = 0.03), and had higher rates of depression (p < .001) and HIV-associated neurocognitive disorder (p = 0.003). Agreement between physical activity measures was sub-optimal. Prevalence of frailty was high among PWH in rural Uganda, but larger sample sizes and local normative data are needed.

Indexed as

Activities of Daily LivingAdultAgedAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCross-Sectional StudiesDepressionExerciseFemaleFrailtyHIV InfectionsHumansMaleMiddle AgedNeurocognitive DisordersPrevalenceAnti-HIV AgentsARTFrailtyGlobal HealthHIVNeuropsychologyUganda

Identifiers

PMID33788138
PMCPMC12226783
OpenAlexW3147574540

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.