ArticleNature immunology2021
TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming.
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Article in Nature immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
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Who cites it
34 citing papers in PubMed, 41 citations in OpenAlex.
- Opportunities and challenges for cancer immunotherapy based on antigen cross-presentation.Annals of medicine · 2026Review
- Quantitative nanoscale imaging shows peptide-MHC I complexes are monomeric and spatially regulated in human dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Machine-Learning-Derived, Mechanistically Informed Transcriptomic Signature to Diagnose Active Tuberculosis and Guide Host-Directed Therapy.Diagnostics (Basel, Switzerland) · 2026Article
- The race between viral immune evasion and the MHC class I antigen processing pathway.FEMS microbiology reviews · 2026Review
- Comparative analysis of pan MHC‑I epitopes immunoreactivity on Hantaan virus nucleocapsid protein.International journal of molecular medicine · 2026Article
- Transporter Associated with Antigen Processing Proteins (TAP-1 and TAP-2) Gene Expression of MHC-I Downregulated in Oral Squamous Cell CarcinomaEndocrine, metabolic & immune disorders drug targets · 2026Article
- WDFY4-dependent cross-presentation proceeds via a vacuolar antigen-processing route.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Submicron-Sampling of Living Cells by Macrophages.bioRxiv : the preprint server for biology · 2025Article
- mRNA Cancer Vaccines: From Pandemic Paradigm to Personalized Oncology Therapeutics.Cancer innovation · 2025Review
- Article
- Cross-priming in cancer immunology and immunotherapy.Nature reviews. Cancer · 2025Review
- Identification of TAP2 as a novel immune target in human cancers: insights from integrated bioinformatics and experimental approaches.European journal of medical research · 2025Article
- Alternate MHC I Antigen Presentation Pathways Allow CD8+ T-cell Recognition and Killing of Cancer Cells in the Absence of β2M or TAP.Cancer immunology research · 2025Article
- Cutting Edge: Phagosome-associated Autophagosomes Containing Antigens and Proteasomes Drive TAP-Independent Cross-Presentation.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- A Novel Platinum Resistance-Related Immune Gene Signature for Overall Survival Prediction in Patients with Ovarian Cancer.Biochemical genetics · 2024Article
- Sec22b and Stx4 Depletion Has No Major Effect on Cross-Presentation of PLGA Microsphere-Encapsulated Antigen and a Synthetic Long Peptide In Vitro.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Major histocompatibility complex class I assembly within endolysosomal pathways.Current opinion in immunology · 2023Review
- Recent progress in type 1 classical dendritic cell cross-presentation - cytosolic, vacuolar, or both?Current opinion in immunology · 2023Review
- Bacteria-instructed B cells cross-prime naïve CD8EMBO reports · 2023Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 2 countries.
Gaëtan Barbet *The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.ORCID http://orcid.org/0000-0002-0152-3650
Priyanka Nair-Gupta *Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Michael SchotsaertGlobal Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Stephen T YeungThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Julien MorettiThe Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.ORCID http://orcid.org/0000-0002-3415-9058
Fabian SeyfferPerlmutter Cancer Center, New York University Langone Health, New York, NY, USA.
Giorgi MetreveliGlobal Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Thomas GardnerMolecular Pharmacology and Chemistry Program, Sloan Kettering Institute, New York, NY, USA.
Angela ChoiGlobal Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Domenico TortorellaDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Robert TampéInstitute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0002-0403-2160
Kamal M KhannaPerlmutter Cancer Center, New York University Langone Health, New York, NY, USA.ORCID http://orcid.org/0000-0002-9328-3817
Adolfo García-SastreDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-6551-1827
J Magarian BlanderThe Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA. jmblander@med.cornell.edu.ORCID http://orcid.org/0000-0001-9207-1700
Cornell University · USIcahn School of Medicine at Mount Sinai · USNYU Langone Health · USGoethe University Frankfurt · DEJanssen (United States) · USKettering University · USModerna Therapeutics (United States) · US
Funding
Novel lung resident interstitial macrophage subset with distinct localization and polarizationR01AI143861 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KHANNA, KAMAL MOHAN · 2019 to 2023
$3.3MToll-like receptor control of endocytic antigen cross-presentationR01AI170832 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Julie Magarian Blander · 2023 to 2026
$2.7MMobilizing TAP-independent CD8 T cells through non-canonical cross-presentationR01AI170897 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Julie Magarian Blander · 2023 to 2026
$2.7MThe Regulatory Control Mechanisms of Cross-presentation by Toll-like ReceptorsR01AI073899 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BLANDER, JULIE MAGARIAN · 2008 to 2012
$2.1MNovel vita-vaccine formula combines safety of dead and efficacy of live vaccinesR01AI127658 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI BLANDER, JULIE MAGARIAN · 2016 to 2020
$2.1MNon-Canonical Cross-presentation in Dendritic Cells Upon TAP BlockadeR01AI123284 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI BLANDER, JULIE MAGARIAN · 2016 to 2020
$2.1MIdentification of human cytomegalovirus life cycle stage-specific therapeuticsR01AI139258 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI TORTORELLA, DOMENICO · 2019 to 2022
$1.6MRole of apoptosis in the intestinal epithelium during homeostasis and diseaseR01DK111862 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI BLANDER, JULIE MAGARIAN · 2017 to 2020
$1.5MAdvanced Microscopy Shared Resource FacilityR24CA095823 · NCI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI FRIEDRICH, VICTOR LOUIS · 2002 to 2006
$1.3MAssay development to discover therapeutics against human cytomegalovirusR01AI101820 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI TORTORELLA, DOMENICO · 2013 to 2015
$962kFunctional screening for neutralizing antibodies targeting CMV entry factorsR21AI112318 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI TORTORELLA, DOMENICO · 2014 to 2015
$466kToll-like Receptor Control of MHC Class I EndocytosisR21AI159772 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI BLANDER, JULIE MAGARIAN · 2022 to 2023
$466kNCI NIH HHS F32 CA224438NCI NIH HHS R24 CA095823NIAID NIH HHS HHSN266200700010CNIAID NIH HHS R01 AI073899NIAID NIH HHS R01 AI101820NIAID NIH HHS R01 AI123284NIAID NIH HHS R01 AI127658NIAID NIH HHS R01 AI139258NIAID NIH HHS R01 AI143861NIAID NIH HHS R01 AI170832NIAID NIH HHS R01 AI170897NIAID NIH HHS R21 AI112318NIAID NIH HHS R21 AI159772NIAID NIH HHS R56 AI073899NIDDK NIH HHS R01 DK111862
Abstract
Classic major histocompatibility complex class I (MHC-I) presentation relies on shuttling cytosolic peptides into the endoplasmic reticulum (ER) by the transporter associated with antigen processing (TAP). Viruses disable TAP to block MHC-I presentation and evade cytotoxic CD8
Indexed as
Cross-PrimingAnimalsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily B, Member 2CD8-Positive T-LymphocytesCell ProliferationCells, CulturedCoculture TechniquesDendritic CellsDisease Models, AnimalEndoplasmic ReticulumFemaleGolgi ApparatusHistocompatibility Antigens Class IHost-Pathogen InteractionsHumansATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily B, Member 2Histocompatibility Antigens Class ITap1 protein, mousetransporter associated with antigen processing (TAP)
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.