ArticleArteriosclerosis, thrombosis, and vascular biology2021
HSP25 Vaccination Attenuates Atherogenesis via Upregulation of LDLR Expression, Lowering of PCSK9 Levels and Curbing of Inflammation.
Open access · bronzeAbstract read
In one paragraph
Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- A bibliometric analysis of immunotherapy for atherosclerosis: trends and hotspots prediction.Frontiers in immunology · 2024Pooled it
- Mechanisms of action and therapeutic potential of PCSK9-regulating drugs.Pharmaceutical biology · 2025Review
- Unveiling the role of exercise in modulating plasma heat shock protein 27 levels: insights for exercise immunology and cardiovascular health.Molecular and cellular biochemistry · 2025Review
- Administration of the KFrontiers in pharmacology · 2025Article
- Association Between Serum Levels of Anti-heat Shock Protein 27 Antibody and Liver Cell Injury in Chronic Hepatitis B.Indian journal of clinical biochemistry : IJCB · 2024Article
- Whether and Why Do We Need a Vaccine Against Atherosclerosis? Can We Expect It Anytime Soon?Current atherosclerosis reports · 2024Review
- Atherosclerosis antigens as targets for immunotherapy.Nature cardiovascular research · 2023Review
- Heat shock protein 27 in the pathogenesis of COVID-19 and non-COVID acute respiratory distress syndrome.Cell stress & chaperones · 2023Observational
- Heat Shock Proteins in Tooth Development and Injury Repair.International journal of molecular sciences · 2023Review
- Mechanistic insights into heat shock protein 27, a potential therapeutic target for cardiovascular diseases.Frontiers in cardiovascular medicine · 2023Review
- Proteotoxic stress response in atherosclerotic cardiovascular disease: Emerging role of heat shock factor 1.Frontiers in cardiovascular medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 7 institutions in 4 countries.
Yong-Xiang ChenDepartment of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary Cumming School of Medicine, Alberta, Canada (Y.-X.C., C.S., J.D., C.D., N.M., M.R., V.S., A.A.H., S.B., A.A., A.U.-L., B.G., Z.B., E.R.O.).
Chunhua ShiDepartment of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary Cumming School of Medicine, Alberta, Canada (Y.-X.C., C.S., J.D., C.D., N.M., M.R., V.S., A.A.H., S.B., A.A., A.U.-L., B.G., Z.B., E.R.O.).
Jingti DengDepartment of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary Cumming School of Medicine, Alberta, Canada (Y.-X.C., C.S., J.D., C.D., N.M., M.R., V.S., A.A.H., S.B., A.A., A.U.-L., B.G., Z.B., E.R.O.).
Catherine DiaoDepartment of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary Cumming School of Medicine, Alberta, Canada (Y.-X.C., C.S., J.D., C.D., N.M., M.R., V.S., A.A.H., S.B., A.A., A.U.-L., B.G., Z.B., E.R.O.).
Nadia MaaroufDepartment of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary Cumming School of Medicine, Alberta, Canada (Y.-X.C., C.S., J.D., C.D., N.M., M.R., V.S., A.A.H., S.B., A.A., A.U.-L., B.G., Z.B., E.R.O.).
Matthew RosinDepartment of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary Cumming School of Medicine, Alberta, Canada (Y.-X.C., C.S., J.D., C.D., N.M., M.R., V.S., A.A.H., S.B., A.A., A.U.-L., B.G., Z.B., E.R.O.).
Vipul ShrivastavaDepartment of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary Cumming School of Medicine, Alberta, Canada (Y.-X.C., C.S., J.D., C.D., N.M., M.R., V.S., A.A.H., S.B., A.A., A.U.-L., B.G., Z.B., E.R.O.).
Angie A HuDepartment of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary Cumming School of Medicine, Alberta, Canada (Y.-X.C., C.S., J.D., C.D., N.M., M.R., V.S., A.A.H., S.B., A.A., A.U.-L., B.G., Z.B., E.R.O.).
Sonya BharadwaDepartment of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary Cumming School of Medicine, Alberta, Canada (Y.-X.C., C.S., J.D., C.D., N.M., M.R., V.S., A.A.H., S.B., A.A., A.U.-L., B.G., Z.B., E.R.O.).
Ayinuer AdijiangDepartment of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary Cumming School of Medicine, Alberta, Canada (Y.-X.C., C.S., J.D., C.D., N.M., M.R., V.S., A.A.H., S.B., A.A., A.U.-L., B.G., Z.B., E.R.O.).
Annegret Ulke-LemeeDepartment of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary Cumming School of Medicine, Alberta, Canada (Y.-X.C., C.S., J.D., C.D., N.M., M.R., V.S., A.A.H., S.B., A.A., A.U.-L., B.G., Z.B., E.R.O.).
Brenig GwilymDepartment of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary Cumming School of Medicine, Alberta, Canada (Y.-X.C., C.S., J.D., C.D., N.M., M.R., V.S., A.A.H., S.B., A.A., A.U.-L., B.G., Z.B., E.R.O.).
Alexandria HellmichDepartment of Biochemistry and Molecular Biology, University of South Alabama College of Medicine, Mobile (A.H., W.T.G.).
Christopher MalozziDepartment of Internal Medicine, University of South Alabama Medical Center, Mobile (C.M.).
Zarah BatulanDepartment of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary Cumming School of Medicine, Alberta, Canada (Y.-X.C., C.S., J.D., C.D., N.M., M.R., V.S., A.A.H., S.B., A.A., A.U.-L., B.G., Z.B., E.R.O.).
Jonathan L E DeanKennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, United Kingdom (J.L.E.D.).
F Daniel RamirezDivision of Cardiology, University of Ottawa Heart Institute, Ontario, Canada (F.D.R.).
Jingwen LiuDepartment of Veterans Affairs Palo Alto Health Care System, California (J.L.).
William T GerthofferDepartment of Biochemistry and Molecular Biology, University of South Alabama College of Medicine, Mobile (A.H., W.T.G.).
Edward R O'BrienDepartment of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary Cumming School of Medicine, Alberta, Canada (Y.-X.C., C.S., J.D., C.D., N.M., M.R., V.S., A.A.H., S.B., A.A., A.U.-L., B.G., Z.B., E.R.O.).
Libin Cardiovascular Institute of Alberta · CADeutsche Telekom (Austria) · ATNuffield Orthopaedic Centre · GBUniversity of Ottawa · CAUniversity of South Alabama · USUniversity of South Alabama Medical Center · USVA Palo Alto Health Care System · US
Funding
The Impact of Family Labor Market Status on Access to Health CareP20MD002314 · NIMHD · UNIVERSITY OF SOUTH ALABAMA · PI CROOK, ERROL D · 2007 to 2016
$12.9MNIMHD NIH HHS P20 MD002314
Abstract
[Figure: see text].
Indexed as
AgedAged, 80 and overAnimalsAntibodiesAortaAortic DiseasesAtherosclerosisCase-Control StudiesCholesterolDisease Models, AnimalFemaleHeat-Shock ProteinsHep G2 CellsHumansImmunogenicity, VaccineMaleAntibodiesCholesterolHeat-Shock ProteinsHsbp1 protein, mouseHSPB1 protein, humanMolecular ChaperonesPcsk9 protein, mouseProprotein Convertase 9Receptors, LDLVaccines, SyntheticatherosclerosischolesterolHSP27 heat-shock proteinsinflammationproprotein convertasesreceptors, LDLvaccines
Identifiers
What Socratic holds
Texttitle and abstract
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.