ArticleJournal of clinical medicine2021
The Association of Oxidative Stress in the Uvular Mucosa with Obstructive Sleep Apnea Syndrome: A Clinical Study.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 15 citations in OpenAlex.
- Epithelial NaJournal of sleep research · 2026Article
- iNOS/NOX-mediated stress, telomerase activity, and hTERT expression as potential biomarkers in sleep apnea.Irish journal of medical science · 2026Article
- Lipofuscin: The Missing Link in the Worsening of Obstructive Sleep Apnea.The Laryngoscope · 2026Article
- Association Between Redox and Inflammatory Biomarkers with the Presence and Severity of Obstructive Sleep Apnea.Medicina (Kaunas, Lithuania) · 2025Article
- Oxidative Stress and Inflammation in Hypoxemic Respiratory Diseases and Their Comorbidities: Molecular Insights and Diagnostic Advances in Chronic Obstructive Pulmonary Disease and Sleep Apnea.Antioxidants (Basel, Switzerland) · 2025Review
- Upper airway microcirculation remodeling in obstructive sleep apnea is not driven by endothelial activation.Scientific reports · 2025Article
- Influence of Obstructive Sleep Apnea on Oxidative Stress in Pregnancy.International journal of molecular sciences · 2025Article
- Nocturia and obstructive sleep apnoea.Nature reviews. Urology · 2024Review
- Mandibular Advancement Devices in Obstructive Sleep Apnea and Its Effects on the Cardiovascular System: A Comprehensive Literature Review.Journal of clinical medicine · 2024Review
- The Role of Oxidative Stress and the Potential Therapeutic Benefits ofAntioxidants (Basel, Switzerland) · 2024Review
- Role of Oxidative Stress in the Occurrence and Development of Cognitive Dysfunction in Patients with Obstructive Sleep Apnea Syndrome.Molecular neurobiology · 2024Review
- Association between Obstructive Sleep Apnea and Heart Failure in Adults-A Systematic Review.Journal of clinical medicine · 2023Review
- Investigating the Role of Serum and Plasma IL-6, IL-8, IL-10, TNF-alpha, CRP, and S100B Concentrations in Obstructive Sleep Apnea Diagnosis.International journal of molecular sciences · 2023Article
- Molecular Pathology, Oxidative Stress, and Biomarkers in Obstructive Sleep Apnea.International journal of molecular sciences · 2023Review
- A Case-Control Study on the Changes in High-Sensitivity C-Reactive Protein and Tumor Necrosis Factor-Alpha Levels with Surgical Treatment of OSAS.International journal of molecular sciences · 2022Article
- Elevated Monocytic Interleukin-8 Expression under Intermittent Hypoxia Condition and in Obstructive Sleep Apnea Patients.International journal of molecular sciences · 2021Article
- Asthma and obstructive sleep apnea: Unveiling correlations and treatable traits for comprehensive care.Chronic respiratory diseaseReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hypothesis that individuals with obstructive sleep apnea syndrome (OSAS) demonstrate oxidative stress in the uvular mucosa that correlates with OSAS occurrence was investigated. A total of 128 participants (mean age 45.8, mean body mass index 30.7, female-male ratio 1:20) were divided into the non-OSAS group (apnea-hypopnea index-AHI < 5) and OSAS-group (AHI ≥ 5), in which mild (5 ≤ AHI < 15), moderate (15 ≤ AHI < 30), and severe (AHI ≥ 30) sub-groups were distinguished. Laryngological examination, Epworth Sleep Scale questionnaire, and home sleep study were performed to obtain AHI, mean oxygen saturation, and lowest oxygen saturation. Total oxidative status (TOS) and total antioxidative status (TAS) were assayed in the uvular mucosa taken during palatoplasty or palatopharyngoplasty. The severity of oxidative stress was expressed as oxidative stress index (OSI). Oxidative/reductive imbalance was noted in the mucosa of the uvula of OSAS individuals, and TAS of the uvular mucosa negatively correlated with the severity of this syndrome. TOS and OSI in the mild, moderate, and severe OSAS were higher than in the non-OSAS group, whereas TAS of the uvular mucosa in the OSAS group was lower compared to the non-OSAS group. In conclusion, oxidative stress in the uvular mucosa is associated with the occurrence of OSAS.
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