Evidence map›Paper›PMID 33800828›Full record

ArticleInternational journal of molecular sciences2021

Bioactive Triterpenes of

Giuseppe Mannino, Piera Iovino, Antonino Lauria, Tullio Genova, Alberto Asteggiano, Monica Notarbartolo, Alessandra Porcu, Graziella Serio, Giorgia Chinigò, Andrea Occhipinti and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Development ofBeilstein journal of nanotechnology · 2026
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  7. Effect of LiposomalBiology · 2024
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  8. Review
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  10. Biological Activity and Metabolomics ofAntioxidants (Basel, Switzerland) · 2023
    Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Changes in the Phytochemical Profile and Antioxidant Properties ofInternational journal of molecular sciences · 2022
    Article
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Giuseppe ManninoDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90128 Palermo, Italy.ORCID 0000-0003-0047-978X
Piera IovinoBiosfered S.R.L., 10148 Turin, Italy.
Antonino LauriaDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90128 Palermo, Italy.ORCID 0000-0002-5116-6815
Tullio GenovaDepartment of Life Sciences and Systems Biology, University of Turin, 10123 Turin, Italy.ORCID 0000-0001-7824-8389
Alberto AsteggianoBiosfered S.R.L., 10148 Turin, Italy.ORCID 0000-0001-8480-2059
Monica NotarbartoloDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90128 Palermo, Italy.
Alessandra PorcuAbel Nutraceuticals S.R.L., 10148 Turin, Italy.
Graziella SerioDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90128 Palermo, Italy.
Giorgia ChinigòDepartment of Life Sciences and Systems Biology, University of Turin, 10123 Turin, Italy.
Andrea OcchipintiAbel Nutraceuticals S.R.L., 10148 Turin, Italy.ORCID 0000-0003-2723-6374
Andrea CapuzzoAbel Nutraceuticals S.R.L., 10148 Turin, Italy.ORCID 0000-0002-8479-5730
Claudio MedanaDepartment of Molecular Biotechnology and Health Sciences, University of Torino, 10125 Torino, Italy.ORCID 0000-0002-9772-6814
Luca MunaronDepartment of Life Sciences and Systems Biology, University of Turin, 10123 Turin, Italy.ORCID 0000-0001-9247-4446
Carla GentileDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90128 Palermo, Italy.ORCID 0000-0001-5861-3342
University of Palermo · ITUniversity of Turin · ITEnel (Italy) · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypercholesterolemia is one of the major causes of cardiovascular disease, the risk of which is further increased if other forms of dyslipidemia occur. Current therapeutic strategies include changes in lifestyle coupled with drug administration. Statins represent the most common therapeutic approach, but they may be insufficient due to the onset of resistance mechanisms and side effects. Consequently, patients with mild hypercholesterolemia prefer the use of food supplements since these are perceived to be safer. Here, we investigate the phytochemical profile and cholesterol-lowering potential of

Indexed as

Anticholesteremic AgentsCatalytic DomainCholesterolChromatography, High Pressure LiquidDietary SupplementsDrug Evaluation, PreclinicalFlame IonizationGas Chromatography-Mass SpectrometryHepatocytesHumansHydrogenHydroxymethylglutaryl-CoA Reductase InhibitorsLovastatinModels, MolecularMolecular Docking SimulationPlant GumsAnticholesteremic AgentsCholesterolHydrogenHydroxymethylglutaryl-CoA Reductase InhibitorsLovastatinPlant GumsResins, PlantTriterpenesbreu brancoenzymatic activitygene expressionHMGCRhypercholesterolemiamolecular dockingmonacolinPCSK9PPARαstatin

Identifiers

PMID33800828
PMCPMC7961947
OpenAlexW3135445843

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.