Evidence map›Paper›PMID 33801339›Full record

Trial reportNutrients2021

Association between Single Nucleotide Polymorphisms and Weight Reduction in Behavioural Interventions-A Pooled Analysis.

Christina Holzapfel, Sabine Sag, Johanna Graf-Schindler, Marcus Fischer, Theresa Drabsch, Thomas Illig, Harald Grallert, Lynne Stecher, Christina Strack, Ian D Caterson and 3 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05466097 (Development of Polygenic Risk Score to Predict the Efficacy of Weight Loss Intervention in Children and Adolescents With Obesity), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05466097 unknown statusnot on this mapstarted 2022, after this paper: background citation

Development of Polygenic Risk Score to Predict the Efficacy of Weight Loss Intervention in Children and Adolescents With Obesity

Typeobservational_patient_registrySponsorFar Eastern Memorial HospitalRan2022 to 2025Enrolled300ConditionsObesity, Children
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Christina HolzapfelInstitute for Nutritional Medicine, School of Medicine, Technical University of Munich, 80992 Munich, Germany.
Sabine SagClinic of Internal Medicine II, University Hospital of Regensburg, 93053 Regensburg, Germany.
Johanna Graf-SchindlerInstitute for Nutritional Medicine, School of Medicine, Technical University of Munich, 80992 Munich, Germany.
Marcus FischerClinic of Internal Medicine II, University Hospital of Regensburg, 93053 Regensburg, Germany.
Theresa DrabschInstitute for Nutritional Medicine, School of Medicine, Technical University of Munich, 80992 Munich, Germany.ORCID 0000-0002-2127-8875
Thomas IlligHannover Unified Biobank, Hannover Medical School, 30625 Hannover, Germany.
Harald GrallertInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Lynne StecherInstitute for Nutritional Medicine, School of Medicine, Technical University of Munich, 80992 Munich, Germany.
Christina StrackClinic of Internal Medicine II, University Hospital of Regensburg, 93053 Regensburg, Germany.
Ian D CatersonBoden Collaboration, Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0002-6139-3632
Susan A JebbNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford OX2 6GG, UK.
Hans HaunerInstitute for Nutritional Medicine, School of Medicine, Technical University of Munich, 80992 Munich, Germany.ORCID 0000-0002-1682-5088
Andrea BaesslerClinic of Internal Medicine II, University Hospital of Regensburg, 93053 Regensburg, Germany.
Technical University of Munich · DEUniversity Hospital Regensburg · DEHelmholtz Zentrum München · DEMedizinische Hochschule Hannover · DEThe University of Sydney · AUUniversity of Oxford · GB

Funding

Bundesministerium für Bildung und Forschung German Competence Network Obesity (FKZ: 01GI1320)Seventh Framework Programme EU, LipidomicNetUniversität Regensburg Internal fundsWW International WW International
6 · The paper itself

Abstract

Knowledge of the association between single nucleotide polymorphisms (SNPs) and weight loss is limited. The aim was to analyse whether selected obesity-associated SNPs within the fat mass and obesity-associated (

Indexed as

Polymorphism, Single NucleotideAdultAlpha-Ketoglutarate-Dependent Dioxygenase FTOBody Mass IndexDNA-Binding ProteinsFemaleGenetic Association StudiesGenetic LociGenetic Predisposition to DiseaseGenetic VariationGenotypeHumansMaleMembrane ProteinsMiddle AgedObesityAlpha-Ketoglutarate-Dependent Dioxygenase FTODNA-Binding ProteinsFTO protein, humanMC4R protein, humanMembrane ProteinsReceptor, Melanocortin, Type 4SEC16B protein, humanTMEM18 protein, humangenetic variantgenotypeSNPweight lossweight loss program

Identifiers

PMID33801339
PMCPMC7998423
OpenAlexW3135898372

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.