Evidence mapPaperPMID 33801684Full record

ReviewInternational journal of molecular sciences2021

Exercise-A Panacea of Metabolic Dysregulation in Cancer: Physiological and Molecular Insights.

Steffen H Raun, Kristian Buch-Larsen, Peter Schwarz, Lykke Sylow

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Molecular and Neural Mechanism of Dysphagia Due to Cancer.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Steffen H RaunSection of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0003-2050-505X
Kristian Buch-LarsenDepartment of Endocrinology, Rigshospitalet, 2100 Copenhagen, Denmark.
Peter SchwarzDepartment of Endocrinology, Rigshospitalet, 2100 Copenhagen, Denmark.
Lykke SylowSection of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0003-0905-5932
University of Copenhagen · DK

Funding

Novo Nordisk Fonden NNF18OC0032082Novo Nordisk Fonden NNF20OC0063577Sundhed og Sygdom, Det Frie Forskningsråd 0169-00013BSundhed og Sygdom, Det Frie Forskningsråd 4004-00233Sundhed og Sygdom, Det Frie Forskningsråd 9039-00170B
6 · The paper itself

Abstract

Metabolic dysfunction is a comorbidity of many types of cancers. Disruption of glucose metabolism is of concern, as it is associated with higher cancer recurrence rates and reduced survival. Current evidence suggests many health benefits from exercise during and after cancer treatment, yet only a limited number of studies have addressed the effect of exercise on cancer-associated disruption of metabolism. In this review, we draw on studies in cells, rodents, and humans to describe the metabolic dysfunctions observed in cancer and the tissues involved. We discuss how the known effects of acute exercise and exercise training observed in healthy subjects could have a positive outcome on mechanisms in people with cancer, namely: insulin resistance, hyperlipidemia, mitochondrial dysfunction, inflammation, and cachexia. Finally, we compile the current limited knowledge of how exercise corrects metabolic control in cancer and identify unanswered questions for future research.

Indexed as

Gene Expression Regulation, NeoplasticAdipose TissueAnimalsCachexiaExerciseExercise TherapyHumansHyperlipidemiasInflammationInsulin ResistanceMetabolic DiseasesMiceMitochondriaMuscle, SkeletalNeoplasmsRatsadipose tissuecancercancer cachexiaexerciseinsulin resistancemetabolismskeletal muscle

Identifiers

PMID33801684
PMCPMC8037630
OpenAlexW3151598982

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.