Evidence map›Paper›PMID 33801759›Full record

ArticleInternational journal of environmental research and public health2021

Vitamin D Levels Are Reduced at the Time of Hospital Admission in Sicilian SARS-CoV-2-Positive Patients.

Agostino Gaudio, Andrea Ruben Murabito, Antonella Agodi, Arturo Montineri, Pietro Castellino, D O CoV Research

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Vitamin D Deficiency and Comorbidities as Risk Factors of COVID-19 Infection: A Systematic Review and Meta-analysis.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2022
    Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Performance of Risk Scores in SARS-CoV-2 Infection: A Retrospective Study.International journal of environmental research and public health · 2025
    Observational
  6. Article
  7. Observational
  8. Vitamin D, infections and immunity.Reviews in endocrine & metabolic disorders · 2022
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Agostino GaudioDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-9958-9606
Andrea Ruben MurabitoSan Marco Hospital, 95121 Catania, Italy.
Antonella AgodiDepartment of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, 95123 Catania, Italy.ORCID 0000-0002-4405-8162
Arturo MontineriSan Marco Hospital, 95121 Catania, Italy.
Pietro CastellinoDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
D O CoV Research
University of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID-19) pandemic poses a worldwide healthcare challenge that needs an efficient response. Unfortunately, to date there is no highly effective treatment, so a deep understanding of COVID-19 risk factors could be an important step in treating the disease. Vitamin D affects the immune system in many different ways, and other authors already found that COVID-19 patients have low levels of vitamin D. In our retrospective study, we evaluated the vitamin D status at the time of hospital admission in 50 COVID-19 patients in Sicily, which is the southernmost region of Italy, and compared them with 100 control subjects matched for age and sex. Our data showed markedly low levels of vitamin D in patients with a positive polymerase chain reaction (PCR) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but no association was found with inflammation markers or clinical severity. Vitamin D levels were reduced at the time of hospital admission in Sicilian SARS-CoV-2-positive patients, but it is not clear whether this condition has an impact on the clinical course of COVID-19.

Indexed as

COVID-19SARS-CoV-2HospitalsHumansRetrospective StudiesSicilyVitamin DVitamin DCOVID-19immune systemSicilyvitamin D

Identifiers

PMID33801759
PMCPMC8036292
OpenAlexW3151629366

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.