Evidence map›Paper›PMID 33802289›Full record

ReviewInternational journal of molecular sciences2021

Mitochondrial Calcium Signaling in Pancreatic β-Cell.

Anna Weiser, Jerome N Feige, Umberto De Marchi

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Mitochondrial CaJournal of cellular physiology · 2025
    Review
  3. Review
  4. CaFrontiers in endocrinology · 2024
    Review
  5. Impact of CaBiochimica et biophysica acta. Biomembranes · 2023
    Article
  6. Article
  7. CaBiomedicines · 2023
    Review
  8. Article
  9. CaCells · 2022
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anna WeiserNestlé Research-EPFL Innovation Park, CH-1015 Lausanne, Switzerland.
Jerome N FeigeNestlé Research-EPFL Innovation Park, CH-1015 Lausanne, Switzerland.ORCID 0000-0002-4751-264X
Umberto De MarchiNestlé Research-EPFL Innovation Park, CH-1015 Lausanne, Switzerland.ORCID 0000-0002-6011-5446

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulation of calcium in energized mitochondria of pancreatic β-cells is emerging as a crucial process for pancreatic β-cell function. β-cell mitochondria sense and shape calcium signals, linking the metabolism of glucose and other secretagogues to the generation of signals that promote insulin secretion during nutrient stimulation. Here, we describe the role of mitochondrial calcium signaling in pancreatic β-cell function. We report the latest pharmacological and genetic findings, including the first mitochondrial calcium-targeted intervention strategies developed to modulate pancreatic β-cell function and their potential relevance in the context of diabetes.

Indexed as

AnimalsCalciumCalcium SignalingDiabetes MellitusGlucoseHumansInsulin-Secreting CellsMitochondriaCalciumGlucosecalciumdiabetesinsulin secretionmitochondriaβ-cell

Identifiers

PMID33802289
PMCPMC7959128

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.